Verbal and Figural Fluency in Temporal Lobe Epilepsy: Does Hippocampal Sclerosis Affect Performance?
| Autor: | Foteini Christidi, George Papadopoulos, Georgios Velonakis, Anna Siatouni, Efstratios Karavasilis, Stergios Gatzonis, Constantinos Psarros, Evangelia Kararizou, Ioannis Zalonis, Nikolaos Triantafyllou, George Tsivgoulis, Artemios Artemiadis |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Cognitive Neuroscience Audiology Neuropsychological Tests behavioral disciplines and activities Hippocampus 050105 experimental psychology Temporal lobe 03 medical and health sciences Fluency 0302 clinical medicine medicine Verbal fluency test Humans 0501 psychology and cognitive sciences Cognitive rehabilitation therapy Episodic memory Language Psychomotor learning Hippocampal sclerosis Sclerosis 05 social sciences Cognition General Medicine medicine.disease nervous system diseases Psychiatry and Mental health Neuropsychology and Physiological Psychology nervous system Epilepsy Temporal Lobe Female Psychology psychological phenomena and processes 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. 30(2) |
| ISSN: | 1543-3641 |
| Popis: | Background and objectives Clinicians commonly use verbal and nonverbal measures to test fluency in patients with epilepsy, either during routine cognitive assessment or as part of pre- and postsurgical evaluation. We hypothesized that patients with mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis would perform worse than patients with lateral TLE in both verbal and design fluency. Methods We assessed semantic, phonemic, and nonverbal fluency in 49 patients with TLE: 31 with lateral TLE and 18 with mesial TLE plus hippocampal sclerosis. We also gave non-fluency cognitive measures: psychomotor speed, attentional set shifting, selective attention, abstract reasoning, verbal and visual episodic memory, and incidental memory. Results Patients with mesial TLE performed significantly worse on figural fluency than patients with lateral TLE. Even though group differences on verbal fluency measures were not significant, the patients with mesial TLE had a pattern of poorer performance. The patients with mesial TLE scored significantly worse on measures of selective attention, verbal episodic memory, and incidental memory. Conclusions Our study underlines differences in cognitive function between patients with mesial and lateral TLE, particularly in figural fluency. Although we cannot directly assess the role of the hippocampus in cognitive aspects of creative and divergent thinking related to figural fluency, the cognitive discrepancies between these two TLE groups could be ascribed to the mesial TLE hippocampal pathology shown in our study and addressed in the literature on hippocampal involvement in divergent thinking. Our findings could benefit cognitive rehabilitation programs tailored to the needs of patients with TLE. |
| Databáze: | OpenAIRE |
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