Biologically active TGF-β1 is increased in cerebrospinal fluid while it is reduced in serum in multiple sclerosis patients
| Autor: | Jean-Pierre Malin, C. Schweppe, J. D. Rollnik, E. Sindern |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Multiple Sclerosis Time Factors Exacerbation medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Severity of Illness Index Pathogenesis Cerebrospinal fluid Immune system Transforming Growth Factor beta Humans Medicine Age of Onset Analysis of Variance Chi-Square Distribution business.industry Growth factor Multiple sclerosis Albumin General Medicine medicine.disease Cytokine Neurology Case-Control Studies Immunology Disease Progression Female Neurology (clinical) business Biomarkers |
| Zdroj: | Acta Neurologica Scandinavica. 96:101-105 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1997.tb00248.x |
| Popis: | Objectives The polypeptide transforming growth factor-beta 1 (TGF-beta 1) is a product of activated monocytes, among other inflammatory cells, and it affects immune responsiveness, cellular growth and differentiation. TGF-beta 1 has potent T-cell inhibiting activities. It may play an important role in limiting autoimmune inflammation. We were interested about levels of biologically active and total TGF-beta 1 in serum and CSF in patients suffering from multiple sclerosis. Subjects and methods We measured biologically active and total TGF-beta 1 in serum and CSF using ELISA-technique in 64 MS patients with 57 during acute exacerbation of MS and 7 in remission (primary-relapsing: n = 59; primary-progressive: n = 5), 20 healthy subjects, and 21 patients with other non-inflammatory neurological diseases (OND). Results Biologically active TGF-beta 1 in serum was reduced in MS patients compared to controls, on the other hand total TGF-beta 1 was elevated in CSF compared to patients with OND. Biologically active TGF-beta 1 in CSF correlated positively with the duration of the acute relapse in patients with primary-relapsing MS. The more relapses the patients had the higher was biologically active TGF-beta 1 in CSF. Total TGF-beta 1 in CSF correlated with macrophages in CSF and albumin quotient. Conclusion We found that an elevated level of biologically active TGF-beta 1 in CSF might be useful as an indicator of disease limitation while active TGF-beta 1 in serum is reduced in multiple sclerosis. Measuring TGF-beta 1 in body fluids by ELISA techniques produces valid results and might be used for further studies focusing on the role of this cytokine in MS. |
| Databáze: | OpenAIRE |
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