Double lung transplantation in an HIV-positive patient with Mycobacterium kansasii infection
| Autor: | Charles Poirier, Danielle Rouleau, Georges Ambaraghassi, Pasquale Ferraro, Claude Fortin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Mycobacterium Infections Nontuberculous Bronchiolitis obliterans HIV Infections Comorbidity 030230 surgery Liver transplantation Sputum culture 03 medical and health sciences 0302 clinical medicine alpha 1-Antitrypsin Deficiency Internal medicine medicine Humans Lung transplantation Lung Aged Mycobacterium kansasii Transplantation biology medicine.diagnostic_test business.industry HIV Middle Aged Viral Load biology.organism_classification medicine.disease Anti-Bacterial Agents Treatment Outcome surgical procedures operative Infectious Diseases Anti-Retroviral Agents 030211 gastroenterology & hepatology Nontuberculous mycobacteria Tomography X-Ray Computed business Watchful waiting Lung Transplantation |
| Zdroj: | Transplant Infectious Disease. 21:e12999 |
| ISSN: | 1398-2273 |
| DOI: | 10.1111/tid.12999 |
| Popis: | Good outcomes with kidney and liver transplantation in HIV-positive patients have led clinicians to recommend lung transplantation in HIV-positive patients based on extrapolated data. Pre-transplant mycobacterial infection is associated with an increased risk of developing new infection or aggravating existing infection, though it does not contraindicate transplantation in non-HIV-infected patients. However, no data exists regarding the outcome of HIV-positive patients with pre-transplant mycobacterial infection. We report a case of double lung transplantation in a 50-year-old HIV-positive patient with alpha-1 antitrypsin deficiency. Prior to transplantation, Mycobacterium kansasii was isolated in one sputum culture and the patient was considered merely colonized as no clinical evidence of pulmonary or disseminated disease was present. The patient successfully underwent a double lung transplantation. Nontuberculous mycobacterial infection was diagnosed histologically on examination of native lungs. Surveillance and watchful waiting were chosen over treatment of the infection. HIV remained under control post-transplantation with no AIDS-defining illnesses throughout the follow-up. A minimal acute rejection that responded to increased corticosteroids was reported. At 12 months post-transplant, a bronchiolitis obliterans syndrome was diagnosed after a drop in FEV1. No evidence of isolation nor recurrence of nontuberculous mycobacteria was reported post-transplantation. At 15 months post-transplant, the patient remained stable with an FEV1 of 30%. The presence of pre-transplant nontuberculous mycobacterial infection did not translate into recurrence of nontuberculous mycobacterial infection post-transplant. Whether it contributed to bronchiolitis obliterans syndrome remains unknown. |
| Databáze: | OpenAIRE |
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