Low-shrinkage-stress nanocomposite: An insight into shrinkage stress, antibacterial, and ion release properties
| Autor: | Frederico C. Martinho, Michael D. Weir, Xiaohong Wang, Mary Ann S. Melo, Jirun Sun, Ghalia Bhadila, Hockin H.K. Xu, Guadalupe Garcia Fay, Thomas W. Oates |
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| Rok vydání: | 2020 |
| Předmět: |
Calcium Phosphates
Ions Nanocomposite Materials science Composite number Biomedical Engineering Biofilm chemistry.chemical_element Nanoparticle Calcium Phosphate Anti-Bacterial Agents Biomaterials Quaternary Ammonium Compounds Streptococcus mutans chemistry.chemical_compound Chemical engineering chemistry Biofilms Methacrylates Amorphous calcium phosphate Stress Mechanical Shrinkage |
| Zdroj: | Journal of biomedical materials research. Part B, Applied biomaterialsREFERENCES. 109(8) |
| ISSN: | 1552-4981 |
| Popis: | The aims are: (a) To develop the first low-shrinkage-stress nanocomposite with antibacterial and remineralization capabilities through the incorporation of dimethylaminododecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); (b) to investigate the effects of the new composite on biofilm inhibition, mechanical properties, shrinkage stress, and calcium (Ca) and phosphate (P) ion releases. The low-shrinkage-stress resin consisted of urethane dimethacrylate and triethylene glycol divinylbenzyl ether. Composite was formulated with 3% DMAHDM and 20% NACP. Mechanical properties, shrinkage stress, and degree of conversion were evaluated. Streptococcus mutans biofilm growth on composites was assessed. Ca and P ion releases were measured. The shrinkage stress of the low-shrinkage-stress composite containing 3% DMAHDM and 20% NACP was 36% lower than that of traditional composite control (p < 0.05), with similar degrees of conversion of 73.9%. The new composite decreased the biofilm colony-forming unit by 4 log orders and substantially reduced biofilm lactic acid production compared to control composite (p < 0.05). Incorporating DMAHDM to the low-shrinkage-stress composite did not adversely affect the Ca and P ion release. A novel bioactive nanocomposite was developed with low shrinkage stress, strong antibiofilm activity, and high levels of ion release for remineralization, without undermining the mechanical properties and degree of conversion. |
| Databáze: | OpenAIRE |
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