Evaluation of red cell distribution width to platelet ratio as a novel non-invasive index for predicting hepatic fibrosis in patients with chronic hepatitis C
| Autor: | Rabab Salama, Naglaa Zayed, Aisha Elsharkawy, Iman Ramzy, Zeinab Abdellatif, Nader Gamal, Marwa Elsharkawy, Rabab Fouad, Wafaa El Akel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Erythrocyte Indices
Liver Cirrhosis medicine.medical_specialty Logistic regression Gastroenterology 03 medical and health sciences 0302 clinical medicine Chronic hepatitis Fibrosis Internal medicine Positive predicative value Humans Medicine In patient Platelet Stage (cooking) Multidisciplinary Platelet Count business.industry Red blood cell distribution width Gold standard (test) Hepatitis C Chronic medicine.disease Cross-Sectional Studies 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Transient elastography business Hepatic fibrosis |
| Zdroj: | Arab Journal of Gastroenterology. 22:6-11 |
| ISSN: | 1687-1979 |
| DOI: | 10.1016/j.ajg.2020.12.003 |
| Popis: | BACKGROUND AND STUDY AIMS Assessing the extent of fibrosis is an essential part of therapeutic decisions in patients with chronic hepatitis C (CHC). Liver biopsies are the "gold standard" for evaluating liver fibrosis but have many limitations. Thus, noninvasive predictors of fibrosis have been developed. This study aimed to determine the effectiveness of red cell distribution width (RDW) to platelet ratio as a simple noninvasive method for predicting the hepatic fibrosis stage in patients with CHC. PATIENTS AND METHODS This cross-sectional study included 197 Egyptian patients with CHC. A routine pretreatment reference needle liver biopsy was performed. Fib-4, transient elastography (TE) by Fibroscan, AST to Platelet Ratio Index (APRI), and RDW to platelet ratio (RPR) were measured. Predictors of significant fibrosis (Metavir score ≥ F2) and advanced fibrosis (Metavir score ≥ F3) were identified. RESULTS Fib-4, TE, APRI, and RPR values differed significantly when comparing different stages of fibrosis (p |
| Databáze: | OpenAIRE |
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