| Autor: |
Husniye Kantarci, Pablo D. Elvira, Arun P. Thottumkara, Manasi Iyer, Lauren J. Donovan, Micaela Quinn Dugan, Nicholas Ambiel, Emma M. O’Connell, Alejandro Granados, Hong Zeng, Nay L. Saw, Amanda Brosius Lutz, Steven A. Sloan, Erin E. Gray, Khanh V. Tran, Aditi Vichare, Ashley K. Yeh, Alexandra E. Münch, Max Huber, Aditi Agrawal, Maurizio Morri, Mehrdad Shamloo, Thomas Anthony Anderson, Vivianne L. Tawfik, J. Du Bois, J. Bradley Zuchero |
| Rok vydání: |
2023 |
| Popis: |
SUMMARYExcitability—the ability to fire action potentials—is a signature feature of neurons. How neurons become excitable during development, and whether excitability is an intrinsic property of neurons or requires signaling from glial cells, remain unclear. Here we demonstrate that Schwann cells, the most abundant glia in the peripheral nervous system, promote somatosensory neuron excitability during development. We find that Schwann cells secrete prostaglandin E2, which is necessary and sufficient to induce developing somatosensory neurons to express normal levels of voltage-gated sodium channels and fire action potential trains. Inactivating this signaling pathway specifically in Schwann cells selectively impairs the maturation of nociceptor and proprioceptor somatosensory neuron subtypes, leading to corresponding sensory defects in thermoception, inflammatory pain, and proprioception. Our studies thus reveal a cell non-autonomous mechanism by which glia regulate neuronal excitability to enable the development of normal sensory functions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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