Pitavastatin: protection against neuronal retinal damage induced by ischemia-reperfusion injury in rats
| Autor: | Megumi Honjo, Akiomi Takano, Mikiko Fukushima, Takahiro Kawaji, Hidenobu Tanihara, Nina Sagara, Masaru Inatani, Yasuya Inomata |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Retinal Ganglion Cells Time Factors Cell Survival Ischemia Ocular hypertension Pharmacology Neuroprotection Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Retinal Diseases medicine Animals RNA Messenger Enzyme Inhibitors Pitavastatin Dose-Response Relationship Drug Retinal damage business.industry Reverse Transcriptase Polymerase Chain Reaction Retinal medicine.disease Intercellular Adhesion Molecule-1 Sensory Systems Rats Ophthalmology P-Selectin Neuroprotective Agents chemistry Anesthesia Reperfusion Injury Injections Intravenous Quinolines Hydroxymethylglutaryl-CoA Reductase Inhibitors business Reperfusion injury Intracellular medicine.drug |
| Zdroj: | Current eye research. 32(11) |
| ISSN: | 0271-3683 |
| Popis: | To evaluate the neuroprotective effects of pitavastatin against neuronal retinal damage induced by ischemia-reperfusion injury in rats.Ischemia-reperfusion injury was induced in Sprague-Dawley rats using ocular hypertension. Pitavastatin (0.1, 0.5, or 1.0 mg/kg) was given intravenously 12 hr or 5 min before, or 12 or 24 hr after the induction of ischemia-reperfusion injury. Morphometric and retrograde labeling analyses revealed neuroprotective effects when pitavastatin (0.5 mg/kg) was administered 5 min before--even 12 and 24 hr--after induction of ischemia-reperfusion injury. These effects depended on dose; protection was noted at pitavastatin concentrations of 0.5 and 1 mg/kg but not 0.1 mg/kg. Furthermore, preadministration of pitavastatin (0.5 mg/kg) reduced expression of P-selectin and intercellular adhesion molecule-1 at 12 and 24 hr after induction of ischemia-reperfusion injury.As pitavastatin was efficacious in preventing retinal neuronal death, it may be a novel therapeutic modality for ischemic retinal diseases. |
| Databáze: | OpenAIRE |
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