Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides
Autor: | Myung Hwa Kim, Min Kee Park, Mi Soo Choi, Chan Hee Nam, Seung Phil Hong, Byung Cheol Park |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Mycosis fungoides medicine.medical_specialty business.industry PUVA therapy medicine.medical_treatment Amyloidosis Papillary dermis 030106 microbiology Case Report Dermatology medicine.disease Ultraviolet therapy 03 medical and health sciences Secondary cutaneous amyloidosis medicine Electron microscopy business Reticular Dermis Porokeratosis |
Zdroj: | Annals of Dermatology |
ISSN: | 2005-3894 1013-9087 |
Popis: | Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Finally, she reached complete remission of mycosis fungoides. However, new yellowish lesions started to appear 1 year after discontinuing the phototherapy. A physical examination revealed multiple yellowish plaques on both extremities. The plaques were well circumscribed and slightly elevated. All laboratory tests were normal. A biopsy specimen showed multiple nodular deposits of eosinophilic amorphous material in papillary dermis and upper reticular dermis. The deposits represented apple green birefringence on Congo red stain viewed under polarized light. Acellular small nodules in the upper dermis consisted of randomly oriented, non-branching, 6.67~12.7 nm thick amyloid fibrils on electron microscopy. We report an interesting and rare case of secondary cutaneous amyloidosis after narrow-band UVB therapy and PUVA therapy in a patient with mycosis fungoides. |
Databáze: | OpenAIRE |
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