Medication Adherence Using Electronic Monitoring in Severe Psychiatric Illness: 4 and 24 Weeks after Discharge
| Autor: | Seung Hyun Kim, Hyun Chul Youn, Yujin Lee, Moon Soo Lee, Hyun Ghang Jeong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Bipolar disorder Intraclass correlation Medication adherence 03 medical and health sciences Behavioral Neuroscience Social support 0302 clinical medicine Rating scale medicine Pharmacology (medical) In patient Psychiatry business.industry After discharge medicine.disease Drug monitoring Medication Event Monitoring System 030227 psychiatry Psychiatry and Mental health Adherence Schizophrenia Original Article business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| ISSN: | 2093-4327 1738-1088 |
| DOI: | 10.9758/cpn.2019.17.2.288 |
| Popis: | Objective : The purpose of this study was to examine post-hospitalization outpatient drug adherence in patients with severe psychiatric illness, including bipolar disorder and schizophrenia, and to investigate factors associated with drug adherence. Methods : Eighty-one patients diagnosed with schizophrenia or bipolar disorder who were hospitalized due to aggravation of psychiatric symptoms were monitored. At hospitalization, we conducted clinical assessments such as the Clinical Global Impression-Severity, Drug Attitude Inventory, Contour Drawing Rating Scale, Multidimensional Scale of Perceived Social Support scale, and patients demographic factors. We measured drug adherence using the Medication Event Monitoring System (MEMS), pill count, and patients self-report upon out-patients visits, 4 and 24 weeks after discharge. Results : The mean values of the various measures of adherence were as follows: MEMS (4 weeks) 84.8%, pill count (4 weeks) 94.6%, self-report (4 weeks) 92.6%, MEMS (24 weeks) 81.6%, pill count (24 weeks) 90.6%, and self-report (24 weeks) 93.6%. The adherence agreement between MEMS, pill count, and self-report was moderate (4 weeks intraclass correlation [ICC]=0.54, 24 weeks ICC=0.52). Non-adherence (MEMS ≤0.08) was observed in 26.4% of the patients at 4 weeks and 37.7% at 24 weeks. There was a negative correlation between drug adherence assessed 4 weeks after discharge and Contour Drawing Rating Scale difference score (r=-0.282, p＜0.05). A positive correlation was found between drug adherence assessed 24 weeks after discharge and Drug Attitude Inventory (r=0.383, p＜0.01). Conclusion : Patients attitude towards their medication and their degree of physical dissatisfaction influenced post-hospitalization drug adherence in severe psychiatric patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|