Effects of Conventional Mechanical Ventilation Performed by Two Neonatal Ventilators on the Lung Functions of Rabbits with Meconium-Induced Acute Lung Injury
| Autor: | P Kosutova, M. Kolomaznik, M. Jurcek, Daniela Mokra, Katarina Matasova, P. Istona, Andrea Calkovska, Mirko Zibolen, Pavol Mikolka |
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| Rok vydání: | 2016 |
| Předmět: |
Mechanical ventilation
Lung business.industry medicine.medical_treatment rabbit Lung injury General Biochemistry Genetics and Molecular Biology Neonatal ventilators meconium aspiration 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Meconium conventional mechanical ventilation 030225 pediatrics Anesthesia medicine Medicine 030212 general & internal medicine lung injury business General Nursing |
| Zdroj: | Acta Medica Martiniana, Vol 16, Iss 3, Pp 5-13 (2016) |
| ISSN: | 1335-8421 |
| DOI: | 10.1515/acm-2016-0012 |
| Popis: | Severe meconium aspiration syndrome (MAS) in the neonates often requires a ventilatory support. As a method of choice, a conventional mechanical ventilation with small tidal volumes (VTIn the young rabbits, a model of MAS was induced by an intratracheal instillation of a suspension of neonatal meconium (4 ml/kg, 25 mg/ml). After creating the model of MAS, the animals were ventilated with small-volume CMV (frequency 50/min, VTMeconium instillation seriously worsened the gas exchange and induced inflammation and lung edema formation. In the Aura group, slightly lower concentrations of cytokines were found and better gas exchange early after creating the MAS model was observed. However, there were no significant differences in the respiratory parameters between the ventilated groups at the end of experiment (P>0.05).Concluding, the newly developed neonatal version of the ventilator Aura V was found to be fully comparable to widely used neonatal ventilator SLE5000. Results provided by Aura V in CMV ventilation of rabbits with meconium-induced acute lung injury suggest its great potential also for future clinical use, i.e. for ventilation of the neonates with MAS. |
| Databáze: | OpenAIRE |
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