The acute effect of a single very high dose of n-3 fatty acids on coagulation and fibrinolysis
| Autor: | Jørn Munkhof Møller, Niels Svaneborg, K. Varming, Poul Henning Madsen, Lervang Hh, Jørn Dyerberg, Erik Berg Schmidt |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Biology Fibrinogen chemistry.chemical_compound Internal medicine Fatty Acids Omega-3 Plasminogen Activator Inhibitor 1 Fibrinolysis medicine Humans Blood Coagulation Morning chemistry.chemical_classification Triglyceride Factor VII food and beverages Hematology Middle Aged Endocrinology Coagulation chemistry Tissue Plasminogen Activator Immunology Female lipids (amino acids peptides and proteins) sense organs Plasminogen activator Polyunsaturated fatty acid medicine.drug |
| Zdroj: | Thrombosis Research. 67:569-577 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(92)90017-5 |
| Popis: | The objective of the study was to investigate the acute effect of a single very high dose of n-3 PUFA on coagulation and fibrinolysis. Forty healthy volunteers were randomized into two groups to receive either 20 grams of n-3 PUFA or 20 grams of n-6 PUFA as a single dose at 6 p.m. with their evening meal. Coagulation and fibrinolysis were evaluated in the fasting state at 8 a.m. the next morning and compared to values obtained at 8 a.m. the day before, when the participants were on their habitual diets. PAI-1 activity in plasma increased by a mean of 62 % in subjects randomized to receive n-3 PUFA despite that no changes could be demonstrated in t-PA antigen levels. PAI-1 activity was unaltered in the 20 controls receiving n-6 PUFA. Plasma fibrinogen, coagulation factor VII, thrombin-antithrombin complexes and D-dimer did not significantly change after either supplement. The substantial increase in levels of PAI-1 activity in plasma after a single very high dose of n-3 PUFA may limit the usefulness of single very high doses of n-3 PUFA in acute clinical conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|