Ethanol dependence and withdrawal selectively alter localized cerebral glucose utilization
| Autor: | Gerald A. Campbell, Robert R. Rawlings, Forrest F. Weight, Edward Majchrowicz, Michael J. Eckardt, Cheryl A. Marietta |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Inferior colliculus Cerebellum medicine.medical_specialty Substance-Related Disorders Mammillary body Thalamus Central nervous system Deoxyglucose White matter Limbic system Internal medicine Motor system medicine Animals Molecular Biology Brain Chemistry Ethanol Chemistry General Neuroscience Rats Inbred Strains Rats Substance Withdrawal Syndrome Glucose medicine.anatomical_structure Endocrinology Anesthesia Autoradiography Neurology (clinical) Developmental Biology |
| Zdroj: | Brain Research. 584:244-250 |
| ISSN: | 0006-8993 |
| Popis: | The 2-deoxyglucose technique was used to determine local cerebral glucose utilization (LCGU) in over 50 brain regions of rats physically dependent upon ethanol and compared to those of acutely intoxicated and those undergoing an overt ethanol-withdrawal syndrome. Dependent-intoxicated rats (average 3lood ethanol concentration 64 mM) had decreased LCGU in 13/54 regions, including those associated with the limbic system, cerebellum, and motor system. The ethanol withdrawal syndrome was associated with 17/50 gray regions showing an increase, including regions involved with motor function, auditory system, and mammillary bodies-anterior thalamus-cingulate cortex pathway. The most pronounced differences between these groups occurred in regions associated with motor function, cerebellar function, anterior thalamus, and median raphe. Comparisons between dependent-intoxicated and acutely intoxicated rats (average blood ethanol concentration 66 mM) revealed that acute intoxication was associated with a relatively greater reduction in LCGU in regions involved with sensory-related functions, mammillary bodies, and median raphe. With the development of dependence, adaptation occurred in these regions except for inferior colliculus and median raphe. Dependence was also associated with a relative decrease in LCGU in white matter, limbic system, and extrapyramidal motor system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|