Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity
| Autor: | Victoria A. Kopylova, Leonie M. Kamminga, Juliette Legler, Marjo J. den Broeder |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Peroxisome proliferator-activated receptor gamma animal structures In silico Review Article Biology Internal medicine Drug Discovery medicine Pharmacology (medical) Obesity Receptor GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Zebrafish Molecular Biology lcsh:QH301-705.5 Adipogenesis Lipid metabolism Peroxisome biology.organism_classification Endocrinology lcsh:Biology (General) lipids (amino acids peptides and proteins) Peroxisome Proliferator-Activated Receptors (PPARs) Function (biology) |
| Zdroj: | PPAR Research, Vol 2015 (2015) Ppar Research, 2015, pp. 358029 PPAR Research Ppar Research, 2015, 358029 |
| ISSN: | 1687-4765 1687-4757 |
| Popis: | The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this review is to describe the role of PPARs in lipid metabolism, adipogenesis, and obesity and evaluate the zebrafish as an emerging vertebrate model to study the function of PPARs. Zebrafish are an appropriate model to study human diseases, including obesity and related metabolic diseases, as pathways important for adipogenesis and lipid metabolism which are conserved between mammals and fish. This review synthesizes knowledge on the role of PPARs in zebrafish and focuses on the putative function of PPARs in zebrafish adipogenesis. Usingin silicoanalysis, we confirm the presence of five PPARs (pparaa,pparab,pparda,ppardb, andpparg) in the zebrafish genome with 67–74% identity to human and mouse PPARs. During development,pparda/bparalogs andppargshow mRNA expression around the swim bladder and pancreas, the region where adipocytes first develop, whereasppargis detectable in adipocytes at 15 days post fertilization (dpf). This review indicates that the zebrafish is a promising model to investigate the specific functions of PPARs in adipogenesis and obesity. |
| Databáze: | OpenAIRE |
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