Treatment of experimental pulmonary arteriosclerosis with cortisone, heparin and fibrinolysin
| Autor: | D.J. Ferguson, R.J. Krone, M. Gumbinas |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Lung Diseases
medicine.medical_specialty Arteriosclerosis Hypertension Pulmonary In Vitro Techniques Dogs medicine Animals Fibrinolysin Lung business.industry Heparin General Medicine medicine.disease Pulmonary hypertension Surgery Cortisone medicine.anatomical_structure Anesthesia Cortisone acetate Pulmonary artery shunt business medicine.drug Artery |
| Zdroj: | Journal of atherosclerosis research. 6(4) |
| ISSN: | 0368-1319 |
| Popis: | Summary The effect of cortisone, heparin, fibrinolysin, and heparin and fibrinolysin in combination on developing pulmonary arteriosclerosis was studied in dogs in which pulmonary hypertension was produced by a systemic artery to pulmonary artery shunt. Cortisone acetate 2.5–3.5 mg/kg/day was given intramuscularly. Heparin, 500–750 units twice daily, was injected subcutaneously. Fibrinolysin was administered intravenously every other day in doses sufficient to maintain fibrinolytic activity measured a few hours after infusion. Duration of treatment was 1–7 months, beginning either just bef ore hypertension was produced or one month after-ward, but before intimal lesions had appeared. The treated dogs in each group developed the same amount and type of pulmonary arteriosclerosis as the controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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