Autopsy-based morphometric study of coronary atherosclerosis in young adults
| Autor: | K Sreekumari, K P Aravindan, R Thiripurasundari |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
young adults
Adult Male 0301 basic medicine medicine.medical_specialty Adolescent 030106 microbiology Population India Autopsy Constriction Pathologic Coronary Artery Disease Overweight Carotid Intima-Media Thickness General Biochemistry Genetics and Molecular Biology Coronary artery disease Young Adult 03 medical and health sciences autopsy 0302 clinical medicine Risk Factors Internal medicine Humans Medicine 030212 general & internal medicine Young adult education IMR education.field_of_study business.industry General Medicine Atherosclerosis medicine.disease Coronary Vessels Confidence interval Coronary arteries ITI Stenosis medicine.anatomical_structure Original Article Female medicine.symptom business morphometry |
| Zdroj: | The Indian Journal of Medical Research |
| ISSN: | 0971-5916 |
| Popis: | Background & objectives: The burden of cardiovascular diseases is high in Kerala, India, and a considerable proportion of these occur in young people. The objective of this study was to estimate the severity of atherosclerosis in autopsies done for accidental and suicidal deaths in victims below 40 yr of age. Methods: Coronary arteries from 77 autopsies done for unnatural deaths in a population below 40 yr were graded, and the degree of stenosis, intimal thickness index (ITI) and the intima-media ratio (IMR) were measured. Results: There were 65 males and 12 females in the sample. The American Heart Association (AHA) type 3-6 (pathological intimal thickening) was seen in 55.4 per cent [95% confidence interval (CI): 42.5-67.7%] of males and 25 per cent (95% CI: 5.5-57.2%) of females and advanced lesions (type 4-6) in 44.6 per cent (95% CI: 32.3-57.5%) of males and 8.3 per cent (95% CI: 0.2-38.5%) of females. Types 5 or 6 lesions were seen in 32.2 per cent (95% CI: 21.2-45.1%) of males. The mean stenosis was 57.3 per cent in males and 40.6 per cent in females. More than 40 per cent stenosis was seen in 76.6 per cent cases, more than 50 per cent in 54.5 per cent cases and more than 75 per cent stenosis in 14.3 per of the sample. The mean ITI (MIT) was 1.85 and the mean IMR was 4.11. The degree of stenosis, MIT and IMR were significantly associated with male sex, overweight and smoking. Interpretation & conclusions: Morphometric data showed that the degree of atherosclerotic narrowing of coronary arteries in young non-diseased population was high. It portends a danger to the community unless preventive measures are taken up. |
| Databáze: | OpenAIRE |
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