Urinary Uric Acid:Creatinine Ratio, Serum Erythropoietin, and Blood 2,3-Diphosphoglycerate in Patients with Obstructive Sleep Apnea
| Autor: | Leslie G. Olson, Stephen G. Gyulay, James L. McKeon, Nicholas A. Saunders, Anthony Houghton, Michael J. Hensley, John Wlodarczyk, Keith Murree-Allen, John E Dickeson |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Urinary system medicine.medical_treatment Renal function Hypoxemia Positive-Pressure Respiration chemistry.chemical_compound Sleep Apnea Syndromes Internal medicine Humans Medicine Continuous positive airway pressure Hypoxia Erythropoietin 2 3-Diphosphoglycerate Creatinine business.industry Apnea Middle Aged Diphosphoglyceric Acids medicine.disease Circadian Rhythm Uric Acid Obstructive sleep apnea Endocrinology chemistry Cardiology Female medicine.symptom business medicine.drug |
| Zdroj: | American Review of Respiratory Disease. 142:8-13 |
| ISSN: | 0003-0805 |
| DOI: | 10.1164/ajrccm/142.1.8 |
| Popis: | A noninvasive, inexpensive method of excluding significant sleep-associated hypoxemia would be desirable for patients being investigated and treated for obstructive sleep apnea (OSA). Sixty-eight such patients provided specimens before and after sleep studies for estimation of urinary uric acid:creatinine ratio (UA:Cr), serum erythropoietin (EPO), and blood 2,3-diphosphoglycerate (2,3-DPG). Mean (SD) morning 2,3-DPG was higher in 26 patients with overnight hypoxemia than in 42 normoxemic patients (2.54 [0.46] versus 2.24 [0.44] mmol/L; p = 0.01). Neither overnight change nor absolute values of serum EPO or urinary UA:Cr were significantly different between hypoxemic and normoxemic groups. There was a diurnal variation in serum EPO in normoxemic patients (P.M. EPO = 14.8 [7.1] mU/ml; A.M. EPO = 10.7 [7.1] mU/ml; p less than 0.05) but not in hypoxemic patients. Eighteen hypoxemic patients were restudied after using nasal continuous positive airway pressure (nCPAP) for at least 4 wk. Seven normoxemic patients not using nCPAP were restudied after a similar time. There were no significant differences between pretreatment and posttreatment nights in absolute values or percentage overnight change of blood 2,3-DPG or serum EPO in either group. In the hypoxemic (nCPAP) group, overnight change in urinary UA:Cr was lower on the second night (p = 0.04); there was no significant change in the control group. We conclude that although urinary UA:Cr, serum EPO, and 2,3-DPG may be physiologically related to hypoxemia, none of these measures can be used to predict accurately the presence of moderate nocturnal hypoxemia in patients with OSA or in monitoring the effect of their therapy. |
| Databáze: | OpenAIRE |
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