Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan
| Autor: | Teleri Clark, Man-Tat Lau, Yong Qi Lin, G. Gregory Neely, Lisa J. Oyston, Qiao-Ping Wang, Thang M. Khuong |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Cancer Research Physiology lcsh:Medicine Biology Neurotransmission Biochemistry Genetics and Molecular Biology (miscellaneous) Synapse LMNA 03 medical and health sciences 0302 clinical medicine synapse medicine Muscular dystrophy lcsh:QH301-705.5 030304 developmental biology 0303 health sciences Progeria dopaminergic neurons integumentary system aging lcsh:R Neurodegeneration Dopaminergic neurodegeneration medicine.disease lcsh:Biology (General) embryonic structures Molecular Medicine Drosophila Neuroscience Lamin 030217 neurology & neurosurgery |
| Zdroj: | Cell Stress, Vol 2, Iss 9, Pp 225-232 (2018) |
| ISSN: | 2523-0204 |
| Popis: | Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria. Here we investigate the role of neuronal Lamin in regulating age-related phenotypes. Neuronal targeting of Lamin led to shortened lifespan, progressive impairment of motor function and loss of dopaminergic (DA) neurons within the protocerebral anterior medial (PAM) cluster in the Drosophila melanogaster brain. Loss of neuronal Lamin caused an age-related decline in neural physiology, with slower neurotransmission and increased chance of motor circuit failure with age. Unexpectedly, Lamin-dependent decline in motor function was specific for the chemical synapses of the dorsal longitudinal muscle (DLM). Together these findings highlight a central role for Lamin dysfunction in regulating neuronal survival and motor circuit physiology during aging. |
| Databáze: | OpenAIRE |
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