Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds
| Autor: | George E. Barreto, Oscar Hidalgo-Lanussa, Ghulam Md Ashraf, Valentina Echeverria, Eliana Baez-Jurado, Amirhossein Sahebkar, Roberto Cosimo Melcangi, Luis M. Garcia-Segura |
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| Rok vydání: | 2019 |
| Předmět: |
obesity
Cell signaling medicine.medical_specialty oestrogens Neuroactive steroid Endocrinology Diabetes and Metabolism microglia 030209 endocrinology & metabolism Fatty Acids Nonesterified Neuroprotection 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Internal medicine Animals Humans Medicine neurodegenerative diseases Cognitive decline Neuroinflammation Gliogenesis Inflammation Endocrine and Autonomic Systems business.industry Neurogenesis Brain Estrogens lipotoxicity Lipotoxicity neurosteroids business Neuroglia 030217 neurology & neurosurgery estrogens Signal Transduction |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1365-2826 0953-8194 |
| DOI: | 10.1111/jne.12776 |
| Popis: | peer-reviewed The high concentrations of free fatty acids as a consequence of obesity and overweight have become risk factors for the development of different diseases including neurodegenerative ailments. Free fatty acids (FAs) are strongly related to inflammatory events, causing cellular and tissue alterations in the brain, including cell death, deficits in neurogenesis and gliogenesis and cognitive decline. It has been reported that people with a high body mass index have a higher risk of suffering from Alzheimer's disease. Hormones such as estradiol not only have beneficial effects on brain tissue but also exert some adverse effects on peripheral tissues including the ovary and breast. For this reason, some studies have evaluated the protective effect of estrogen receptor (ER) agonists with more specific tissue activities, such as the neuroactive steroid tibolone. Activation of ERs positively affects the expression of pro-survival factors and cell signaling pathways, thus promoting cell survival. This review aims to discuss the relationship between lipotoxicity and the development of neurodegenerative diseases. We also elaborate on the cellular and molecular mechanisms involved in neuroprotection induced by estrogens. ACCEPTED peer-reviewed |
| Databáze: | OpenAIRE |
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