5-Fluorouracil Infusion Reduces Gut-Associated Lymphoid Tissue Cell Number and Mucosal Immunoglobulin A Levels
| Autor: | Hidetoshi Nagayoshi, Hidetaka Mochizuki, Etsuko Hara, Hoshio Hiraide, Chikara Ueno, Jiro Omata, Yoshinori Maeshima, Kazuhiko Fukatsu |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male 0301 basic medicine Immunoglobulin A Antimetabolites Antineoplastic medicine.medical_specialty Lymphoid Tissue Gut-associated lymphoid tissue CD4-CD8 Ratio Medicine (miscellaneous) CD8-Positive T-Lymphocytes Enteral administration Mice Random Allocation 03 medical and health sciences Internal medicine Intestine Small medicine Animals Lymphocytes Intestinal Mucosa Mice Inbred ICR Lamina propria 030109 nutrition & dietetics Nutrition and Dietetics biology Flow Cytometry Small intestine 030104 developmental biology medicine.anatomical_structure Lymphatic system Endocrinology biology.protein Parenteral Nutrition Total Fluorouracil CD8 Respiratory tract |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 29:395-400 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1177/0148607105029006395 |
| Popis: | Background: Anticancer drugs have been demonstrated to affect gut mucosal morphology and cause gastrointestinal symptoms. We hypothesized that even small doses of 5-fluorouracil (5-FU) would reduce gut-associated lymphoid tissue (GALT) mass and function. Methods: Mice underwent IV cannulation and received continuous infusion of normal saline or 10 mg/kg of 5-FU for 5 days. GALT cell numbers, phenotypes, and mucosal immunoglobulin A (IgA) levels were measured. Results: During the infusion, there were no significant differences in food intake or body weight change between the 2 groups. Cell yields from the intraepithelial space and lamina propria of the small intestine were lower in the 5-FU than the control group. The lamina propria CD4/CD8 ratio was reduced in the 5-FU compared with the control group. Intestinal and respiratory tract IgA levels were lower in the 5-FU than in the control group. Conclusions: A small dose of 5-FU reduces GALT cell number and mucosal IgA levels, regardless of food intake. |
| Databáze: | OpenAIRE |
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