Clinicopathological and Molecular Features of Patients with Early and Late Recurrence after Curative Surgery for Colorectal Cancer
| Autor: | Yuan Tzu Lan, Pei Ching Lin, Chun Chi Lin, Chien Hsing Lin, Hung Hsin Lin, Jeng Kai Jiang, Shih Ching Chang, Sheng Chieh Huang, Jen Kou Lin, Shung Haur Yang, Wei Shone Chen, Wen Yi Liang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Neuroblastoma RAS viral oncogene homolog Oncology Cancer Research medicine.medical_specialty Multivariate analysis Colorectal cancer early recurrence colorectal cancer lcsh:RC254-282 Article Metastasis 03 medical and health sciences 0302 clinical medicine genetic alteration Internal medicine Late Recurrence medicine late recurrence Stage (cooking) prognostic factor Pathological business.industry lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease digestive system diseases 030104 developmental biology 030220 oncology & carcinogenesis Curative surgery business |
| Zdroj: | Cancers Volume 13 Issue 8 Cancers, Vol 13, Iss 1883, p 1883 (2021) |
| ISSN: | 2072-6694 |
| Popis: | Background: Few reports have investigated genetic alterations between patients with early and late recurrence following curative surgery for colorectal cancer (CRC). Methods: A total of 1227 stage I–III CRC patients who underwent curative resection were included retrospectively. Among them, 236 patients had tumor recurrence: 139 had early (< 2 years after surgery) and 97 had late (≥2 years after surgery) recurrence. Clinicopathological features and genetic alterations were compared between the two groups. Results: Compared to those with late recurrence, patients with early recurrence were more likely to have advanced pathological node (N) categories tumor, node, metastasis (TNM) stages adjuvant chemotherapy treatment liver metastases APC mutations and worse five-year overall survival rates. Patients with right-sided colon cancer were more likely to develop early recurrence than were those with left-sided colon cancer or rectal cancer. Regarding rectal cancer, patients with early recurrence were more likely to be at advanced pathological N categories and TNM stages than those with late recurrence. Multivariate analysis revealed old age, early recurrence, multiple-site recurrence, and BRAF and NRAS mutations to be independent prognostic factors. Conclusion: CRC patients with early recurrence have a worse OS rate and more APC mutations than those with late recurrence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|