Polymorphisms ofCOMTandXPDand risk of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China
| Autor: | Jun-guo Feng, Xiaomei Lu, Tao Liu, Guo-dong, Cong-gai Huang, Qing Liu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Oncology China medicine.medical_specialty Esophageal Neoplasms Genotype Health Toxicology and Mutagenesis Clinical Biochemistry Population Catechol O-Methyltransferase Polymorphism Single Nucleotide Biochemistry Esophageal squamous cell carcinoma Asian People Gene Frequency Risk Factors Internal medicine Humans Medicine Genetic Predisposition to Disease Comt gene Allele education Aged Xeroderma Pigmentosum Group D Protein Aged 80 and over Genetics education.field_of_study business.industry Odds ratio Middle Aged Increased risk Carcinoma Squamous Cell Female business rs4680 |
| Zdroj: | Biomarkers. 16:37-41 |
| ISSN: | 1366-5804 1354-750X |
| DOI: | 10.3109/1354750x.2010.522732 |
| Popis: | Objective: To investigate polymorphisms of COMT (Rs4680) and XPD (Rs13181) and risk of esophageal squamous cell carcinoma (ESCC) in a population from Yili Prefecture, Xinjiang, China.Methods: A hospital-based case–control study was designed. Genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). Odds ratios (OR) and 95% confidence intervals (CI) were analysed using unconditional logistic regression.Results: An increased risk of ESCC was discovered with COMT in relation to the frequency of the presence of the A allele (Rs4680; OR 1.30, 95% CI 1.00–1.68). An individual with combined COMT 158 (Val/Met or Met/Met) and XPD 751 (Lys/Gln or Gln/Gln) genotype had an increased ESCC risk.Conclusions: Polymorphic variation in COMT Val158Met and XPD Lys751Gln may be important for ESCC susceptibility. |
| Databáze: | OpenAIRE |
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