Vitamin D and the Risks of Depression and Anxiety: An Observational Analysis and Genome-Wide Environment Interaction Study
| Autor: | Shiqiang Cheng, Yujing Chen, Huijie Zhang, Chuyu Pan, Yan Wen, Feng Zhang, Jingxi Zhang, Peilin Meng, Yumeng Jia, Xuena Yang, Zhen Zhang, Chun'e Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Multifactorial Inheritance medicine.medical_specialty Candidate gene Genome-wide association study vitamin D Logistic regression Polymorphism Single Nucleotide Article Genotype-phenotype distinction Risk Factors Internal medicine medicine Vitamin D and neurology Humans TX341-641 Depression (differential diagnoses) Biological Specimen Banks Nutrition and Dietetics genome-wide association study Genome Human business.industry Nutrition. Foods and food supply Middle Aged anxiety Cohort depression polygenic risk score genome-wide environment interaction study Regression Analysis Anxiety Female Gene-Environment Interaction medicine.symptom business Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 3343, p 3343 (2021) Nutrients Volume 13 Issue 10 |
| ISSN: | 2072-6643 1140-8618 |
| Popis: | Previous studies have suggested that vitamin D (VD) was associated with psychiatric diseases, but efforts to elucidate the functional relevance of VD with depression and anxiety from genetic perspective have been limited. Based on the UK Biobank cohort, we first calculated polygenic risk score (PRS) for VD from genome-wide association study (GWAS) data of VD. Linear and logistic regression analysis were conducted to evaluate the associations of VD traits with depression and anxiety traits, respectively. Then, using individual genotype and phenotype data from the UK Biobank, genome-wide environment interaction studies (GWEIS) were performed to identify the potential effects of gene × VD interactions on the risks of depression and anxiety traits. In the UK Biobank cohort, we observed significant associations of blood VD level with depression and anxiety traits, as well as significant associations of VD PRS and depression and anxiety traits. GWEIS identified multiple candidate loci, such as rs114086183 (p = 4.11 × 10−8, LRRTM4) for self-reported depression status and rs149760119 (p = 3.88 × 10−8, GNB5) for self-reported anxiety status. Our study results suggested that VD was negatively associated with depression and anxiety. GWEIS identified multiple candidate genes interacting with VD, providing novel clues for understanding the biological mechanism potential associations between VD and psychiatric disorders. |
| Databáze: | OpenAIRE |
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