Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities
| Autor: | Harriet J Rogers, Olli Gröhn, Bryony L. McGarry, Risto A. Kauppinen, Michael J. Knight, Kimmo Jokivarsi |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Fluid-attenuated inversion recovery Signal Functional Laterality Brain Ischemia Time-to-Treatment Nuclear magnetic resonance Occlusion Medicine Effective diffusion coefficient Animals Rats Wistar Stroke medicine.diagnostic_test business.industry General Neuroscience Brain Magnetic resonance imaging Infarction Middle Cerebral Artery Signal Processing Computer-Assisted medicine.disease Magnetic Resonance Imaging Disease Models Animal Diffusion Tensor Imaging Anesthesia Relaxation (physics) Protons business Diffusion MRI |
| Zdroj: | Neuroreport. 25(15) |
| ISSN: | 1473-558X |
| Popis: | One in four ischaemic stroke patients are ineligible for thrombolytic treatment due to unknown onset time. Quantification of absolute MR relaxation times and signal intensities are potential methods for estimating stroke duration. We compared the accuracy of these approaches and determined whether changes in relaxation times and signal intensities identify the same ischaemic tissue as diffusion MRI. Seven Wistar rats underwent permanent middle cerebral artery occlusion to induce focal ischaemia and were scanned at six time points. The trace of the diffusion tensor (DAV), T1ρ and T2 were acquired at 4.7 T. Results show relaxation times, and signal intensities of the MR relaxation parameters increase linearly with ischaemia duration (P |
| Databáze: | OpenAIRE |
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