Significance of cyclooxygenase-2 in oncogenesis
| Autor: | A. Pomianowski, Andrzej Rychlik, Izabella Babińska, M. Szweda |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Gene isoform
040301 veterinary sciences Veterinary medicine Inflammation Review Article Biology medicine.disease_cause 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Immune system oncogenesis SF600-1100 medicine cox-2 expression mechanisms Pathological General Veterinary Cancer 04 agricultural and veterinary sciences medicine.disease cyclooxygenase-2 Apoptosis 030220 oncology & carcinogenesis biology.protein Cancer research Cyclooxygenase medicine.symptom Carcinogenesis |
| Zdroj: | Journal of Veterinary Research, Vol 63, Iss 2, Pp 215-224 (2019) Journal of Veterinary Research |
| ISSN: | 2450-8608 |
| DOI: | 10.2478/jvetres-2019-0030 |
| Popis: | The cyclooxygenase-2 (COX-2) enzyme catalyses the first stage of biosynthesis of prostanoids, proteins that are implicated in various physiological and pathological processes in humans and animals. The expression of COX-2 increases significantly during pathological processes accompanied by inflammation, pain and fever. Overexpression of COX-2 was determined in tumour tissues, which suggests that this enzyme participates in oncogenesis. In this paper the topics discussed are mechanisms regulating COX-2 expression, COX isoforms, their role in the body and the oncogenic mechanisms triggered by the overexpression of COX-2, including inhibition of apoptosis, intensification of neoangiogenesis, increased metastatic capacity, and weakening of the immune system. The significance of and the mechanisms by which COX-2 participates in oncogenesis have been studied intensively in recent years. The results are highly promising, and they expand our understanding of the complex processes and changes at the molecular, cellular and tissue level that promote oncogenesis and cancer progression. Notwithstanding the knowledge already gleaned, many processes and mechanisms have not yet been elucidated in human medicine and, in particular, in veterinary medicine. Further research is required to develop effective tumour diagnostic methods and treatment procedures for humans and animals. |
| Databáze: | OpenAIRE |
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