Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity
| Autor: | Hiten D. Mistry, Lesia O. Kurlak, M. M. Ramsay, Michael E. Symonds, Fiona Broughton Pipkin, Joanna Mather |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Fetus Homocysteine Obstetrics business.industry Obstetrics and Gynecology Maternal morbidity Hospital based Normotensive pregnancy chemistry.chemical_compound Endocrinology chemistry Internal medicine Plasma concentration Internal Medicine medicine Plasma homocysteine Parity (mathematics) business |
| ISSN: | 2210-7789 |
| Popis: | Pre-eclampsia affects between 2-7% of all pregnant women, contributing to perinatal and maternal morbidity. There are conflicting data on plasma homocysteine and folate in pre-eclampsia, and little about fetal concentrations. Objectives: Firstly, to compare the concentrations of homocysteine and folate in maternal and paired fetal (umbilical venous) plasma samples from normotensive or pre-eclamptic pregnancies at delivery; secondly, to identify any effect of parity on these concentrations. Study design: Hospital based cross-sectional study consisting of 24 normotensive and 16 pre-eclamptic pregnant White European women from whom maternal and fetal plasma samples were collected at delivery. Main outcome measures: Maternal and fetal plasma homocysteine and folate concentrations between normotensive and pre-eclamptic pregnancies with varying parity.Results: There were no significant differences in either maternal or fetal plasma homocysteine or folate concentrations between normotensive and pre-eclamptic pregnancies, or between homocysteine and folate. In both the normotensive and pre-eclamptic women, plasma folate concentration was higher in paired fetal compared to maternal plasma (P < 0.001 and P = 0.047 respectively). With regards to homocysteine, only the normotensive samples had higher fetal concentrations (P = 0.002). Both maternal and fetal plasma folate concentrations were lower in parous women (P = 0.001; P = 0.017 respectively), the lowest concentrations being in pre-eclamptic parous women (P = 0.004), but homocysteine concentrations were similar (P > 0.4 for both). Conclusions: The low plasma folate in parous women is an interesting finding and, when intake is also low, may contribute to adverse pregnancy outcomes, particularly in relation to pre-eclampsia. |
| Databáze: | OpenAIRE |
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