Chronic hepatitis B: correlation of abnormal features on T2-weighted imaging and dynamic contrast-enhanced imaging with hepatic histopathology
| Autor: | Guang Cai Tang, Jian Nong Zhao, Xin Chen, Fu Gang Han, Jian Shu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Image-Guided Biopsy Male Pathology medicine.medical_specialty Adolescent Contrast Media Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Fibrosis Edema Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Pathological Neuroradiology Retrospective Studies medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Hyperintensity Case-Control Studies Reticular connective tissue 030211 gastroenterology & hepatology Histopathology Female medicine.symptom business |
| Zdroj: | La Radiologia medica. 122(11) |
| ISSN: | 1826-6983 |
| Popis: | To investigate the correlations between abnormal features on liver magnetic resonance (MR) T2-weighted imaging (T2WI) and dynamic contrast-enhanced (DCE) imaging and the pathological findings in chronic hepatitis B. Sixty-seven patients with chronic hepatitis B and 18 normal controls who were undergone an abdominal MR imaging were analyzed retrospectively. Patchy hyperintensities, linear and reticular hyperintensities in liver and periportal edema on T2WI and abnormal intrahepatic enhancement signals on DCE imaging were noted. The correlations between the abnormal features detected on hepatic T2WI and DCE imaging, and the levels of inflammatory activity and fibrosis were determined. Logistic regression analysis showed increased patchy hyperintensities (B = 1.869, P = 0.001) on T2WI and patchy enhancement (B = 1.596, P = 0.004) at the arterial phase along with increased inflammatory activity. However, linear and reticular hyperintensities (B = 2.356, P = 0.000) on T2WI, and meshwork enhancement (B = 2.191, P = 0.000) at the equilibrium phase, all correlated with fibrosis. Moreover, periportal edema mainly correlated with the inflammatory activities (B = 2.635, P = 0.001). In chronic hepatitis B patients, patchy hyperintensities on T2WI, periportal edema, and patchy enhancement at the arterial phase can predict moderate-to-severe inflammatory activities, whereas intrahepatic linear and reticular hyperintensities on T2WI, and meshwork enhancement at the equilibrium phase can predict moderate-to-severe fibrosis. |
| Databáze: | OpenAIRE |
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