Mitochondrial targeting of quinones: Therapeutic implications
| Autor: | Victoria J. Adlam, Andrew M. James, Geoffrey F. Kelso, Jordi Asin-Cayuela, Thabo Mahendiran, Robin A.J. Smith, Frances H. Blaikie, Helena M. Cochemé, Carolyn M. Porteous, Abdul-Rahman B. Manas, Michael P. Murphy, Meredith F. Ross, Jan Trnka |
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| Rok vydání: | 2007 |
| Předmět: |
Mitochondrial Diseases
Ubiquinone Administration Oral Analogs & derivatives Mitochondrion Biology Models Biological Membrane Potentials Cell membrane chemistry.chemical_compound Organophosphorus Compounds Cations medicine Animals Humans Molecular Biology Membrane Potential Mitochondrial Membrane potential MitoQ Cell Membrane Quinones Biological membrane Cell Biology Metabolism In vitro Mitochondria Cell biology Oxygen medicine.anatomical_structure Models Chemical Biochemistry chemistry Molecular Medicine |
| Zdroj: | Mitochondrion. 7:S94-S102 |
| ISSN: | 1567-7249 |
| DOI: | 10.1016/j.mito.2007.02.007 |
| Popis: | Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria. Conjugation of the lipophilic triphenylphosphonium cation to a ubiquinone moiety has produced a compound, MitoQ, which accumulates selectively into mitochondria. MitoQ passes easily through all biological membranes and, because of its positive charge, is accumulated several hundred-fold within mitochondria driven by the mitochondrial membrane potential. MitoQ protects mitochondria against oxidative damage in vitro and following oral delivery, and may therefore form the basis for mitochondria-protective therapies. |
| Databáze: | OpenAIRE |
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