G Protein-Coupled Receptors in Anopheles gambiae

Autor:	Mathew A. Chrystal, A. Nicole Fox, R. Jason Pitts, Lauren B. Kent, Catherine A. Hill, Anibal Cravchik, Perciliz L. Tan, Laurence J. Zwiebel, Hugh M. Robertson, Frank H. Collins
Rok vydání:	2002
Předmět:	G protein Anopheles gambiae Molecular Sequence Data Gene Expression Genes Insect Receptors Cell Surface Receptors Odorant Rhodopsin-like receptors Evolution Molecular GTP-Binding Proteins Molecular evolution Anopheles Animals Drosophila Proteins Amino Acid Sequence Receptor Gene Conserved Sequence Phylogeny G protein-coupled receptor Genetics Genome Multidisciplinary biology Reverse Transcriptase Polymerase Chain Reaction Gene Amplification Computational Biology biology.organism_classification Alternative Splicing Drosophila melanogaster Multigene Family Insect Proteins Signal Transduction
Zdroj:	Science. 298:176-178
ISSN:	1095-9203 0036-8075
Popis:	We used bioinformatic approaches to identify a total of 276 G protein–coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster . Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62d94364891e010141fb839060141da https://doi.org/10.1126/science.1076196 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.