The spectrum of Vogt-Koyanagi-Harada disease in Tunisia, North Africa
| Autor: | Sonia Zaouali, Sami Chaabane, K. Hmidi, Salim Ben Yahia, Sonia Attia, Riadh Messaoud, Moncef Khairallah |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Vogt–Koyanagi–Harada disease medicine.medical_specialty Tunisia Visual acuity Adolescent Visual Acuity Glaucoma Age Distribution Ophthalmology medicine Humans Age of Onset Sex Distribution Glucocorticoids Retrospective Studies business.industry Panuveitis Retrospective cohort study Middle Aged medicine.disease Dermatology eye diseases Choroidal neovascularization Female Age of onset medicine.symptom Uveomeningoencephalitic Syndrome business Immunosuppressive Agents Uveitis |
| Zdroj: | International Ophthalmology. 27:125-130 |
| ISSN: | 1573-2630 0165-5701 |
| DOI: | 10.1007/s10792-006-9013-x |
| Popis: | Objective To analyze the clinical profile of Vogt-Koyanagi-Harada (VKH) disease in Tunisia, North Africa. Methods We retrospectively reviewed the clinical records of 49 patients diagnosed with VKH disease at the Department of Ophthalmology of Fattouma Bourguiba University Hospital, Monastir, Tunisia, between January 1994 and September 2005. Results Of all the uveitis cases diagnosed during the study period, VKH disease was the fourth most commonly occurring type (7.4%). Thirty-two patients (65.3%) were female, and 17 patients (34.7%) were male. The mean age at disease onset was 35 years (range: 16–54 years). The majority of patients (51%) had probable VKH disease, followed by incomplete type (47%); only 2% had the complete type. At presentation, 47 patients (96%) had bilateral ocular involvement. Clinical presentation was a panuveitis in 25 patients (51%) and a posterior uveitis in 24 patients (49%). Visual acuity (VA) at presentation ranged from less than 20/200 (40.8%) to more than 20/40 (28.5%). All patients were treated with systemic corticosteroids for 2–19 months (mean: 10.5 months). Four patients (8%) were treated with cyclosporin because of serious systemic side effects of corticosteroids. Complications included cataract in 18 eyes (33.9%), glaucoma in nine eyes (16.96%) and choroidal neovascularization in one eye (1%). Fifty-eight eyes (59%) had a final VA of 20/40 or better. Factors associated with a poor VA at the final follow-up were the presence of a poor VA at presentation (P = 0.02), the occurrence of complications (P = 0.001) and/or recurrences (P = 0.02). Conclusion In Tunisia, VKH disease is a common cause of uveitis that predominantly affects young women. The overwhelming majority (98%) have probable or incomplete VKH disease, presenting as panuveitis or posterior uveitis. More than 50% of patients undergoing treatment with corticosteroids will maintain a VA of 20/40 or better. |
| Databáze: | OpenAIRE |
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