Extract and molecular‐based early infant sensitization and associated factors—A PreventADALL study
| Autor: | Anna Asarnoj, Christine M. Jonassen, Jon R Konradsen, Magnus P. Borres, Live Solveig Nordhagen, Cilla Söderhäll, Eva Maria Rehbinder, Gunilla Hedlin, Hrefna Katrín Gudmundsdóttir, Ina Kreyberg, Caroline-Aleksi Olsson Mägi, Knut Rudi, Karen Eline Stensby Bains, Håvard Ove Skjerven, Guttorm Haugen, Karin C. Lødrup Carlsen, Anne Cathrine Staff, Riyas Vettukattil, Marianne van Hage, Sandra G Tedner, Björn Nordlund, Sabina Wärnberg Gerdin, Kai-Håkon Carlsen, Martin Färdig |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Allergy Arachis molecular allergology Immunology Immunoglobulin E sensitization Cohort Studies Allergic sensitization 03 medical and health sciences Dogs 0302 clinical medicine Casein medicine Animals Immunology and Allergy Sensitization Pregnancy biology business.industry food and beverages birth cohort Odds ratio Allergens medicine.disease 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Cohort Cats biology.protein IgE business immunoglobulin E antibodies Food Hypersensitivity |
| Zdroj: | Allergy. European Journal of Allergy and Clinical Immunology |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | Background: More knowledge about sensitization patterns in early infancy, including impact of molecular allergology, is needed to help predict future allergy development more accurately. Objective: We aimed to determine the prevalence and patterns of allergic sensitization at 3 months of age, and explore possible associated factors. Methods: From the Scandinavian antenatally recruited PreventADALL mother–child cohort, we included 1110 3-month infants with available serum. Sensitization was defined as s-IgE of ≥0.1 kUA/L by Phadiatop Infant® (ThermoFisher Scientific) including birch, cat, grass, dog, milk, egg, peanut and wheat. Further ImmunoCAP analyses to ovomucoid, casein, Ara h 1-3, omega-5-gliadin were performed in food extract s-IgE-positive children. Maternal sensitization was defined as s-IgE ≥ 0.35 kUA/L to Phadiatop® (inhalant allergen mix) and/or Fx5 (food allergen mix) at 18-week pregnancy. Results: Overall 79 (7.3%) infants had specific sensitization, many with low s-IgE-levels (IQR 0.16–0.81 kUA/L), with 78 being sensitized to food extract allergens; 41 to egg, 27 to milk, 10 to peanut, and 25 to wheat. A total of 62/78 were further analysed, 18 (29%) had s-IgE to ovomucoid, casein, Ara h 1-3 and/or omega-5-gliadin. Eight infants (0.7%) were sensitized to inhalant allergens. Maternal sensitization to food allergens was associated with infant sensitization, odds ratio 3.64 (95% CI 1.53–8.68). Conclusion: Already at 3 months of age, 7% were sensitized to food, mostly without detectable s-IgE to food allergen molecules, and |
| Databáze: | OpenAIRE |
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