Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

Autor: Christos Tzimos, Pantelis Zebekakis, Maria G. Grammatikopoulou, Barbara Nikolaidou, Antonios Lazaridis, Nikolaos Koletsos, Eugenia Gkaliagkousi, Panagiota Anyfanti, Stella Douma, Anastasios Vamvakis, Areti Triantafyllou
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
hypertension
asymmetric dimethylarginine
Blood Pressure
030209 endocrinology & metabolism
lcsh:TX341-641
030204 cardiovascular system & hematology
Arginine
Essential hypertension
Carotid Intima-Media Thickness
Severity of Illness Index
Article
endothelial dysfunction
law.invention
03 medical and health sciences
chemistry.chemical_compound
Vascular Stiffness
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Humans
Healthy Lifestyle
Medical nutrition therapy
Endothelial dysfunction
Univariate analysis
Nutrition and Dietetics
business.industry
Middle Aged
medicine.disease
Exercise Therapy
Treatment Outcome
Blood pressure
chemistry
inflammation
Arterial stiffness
Cardiology
dietary inflammatory index
Female
Endothelium
Vascular
business
Asymmetric dimethylarginine
lcsh:Nutrition. Foods and food supply
Diet Therapy
Food Science
medical nutrition therapy
Zdroj: Nutrients, Vol 12, Iss 1326, p 1326 (2020)
Nutrients
Volume 12
Issue 5
ISSN: 2072-6643
Popis: Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, &beta
stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion (p &le
0.001), daytime systolic BP (p &le
0.048) and mean carotid &beta
stiffness index (p &le
0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (&beta
= 0.089, p &le
0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness.
Databáze: OpenAIRE
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