Reticular rash in drug reaction with eosinophilia and systemic symptoms syndrome: A clue to parvovirus B19 reactivation?
| Autor: | M J Cura, Ana Clara Torre, Julia Riganti, Karen Yoselin Cueto Sarmiento, Luis Daniel Mazzuoccolo, Laura Barcan, Juan Bautista Blanco, María Luz Bollea Garlatti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
viruses medicine.medical_treatment Dermatology Disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Eosinophilia Case Series Parvoviridae Chemotherapy biology medicine.diagnostic_test Parvovirus business.industry virus diseases biology.organism_classification Rash 030104 developmental biology medicine.anatomical_structure Skin biopsy Immunology Bone marrow medicine.symptom business |
| Zdroj: | JAAD Case Reports |
| ISSN: | 2352-5126 |
| Popis: | The term drug reaction with eosinophilia and systemic symptoms (DRESS) refers to a complex syndrome characterized by cutaneous lesions, eosinophilia, and systemic symptoms that may be triggered by different medications. The reaction takes place 2 to 6 weeks after the initial exposure to the culprit drug.1 Even after appropriate diagnosis and treatment have been conducted, patients may experience isolated or sequential relapses and slow clinical resolution that may be associated with viral reactivations of herpesvirus.2 Parvovirus B19 is a small, nonenveloped single-stranded DNA virus of the Parvoviridae family.3 It is well known for its ability to persist in blood and bone marrow in immunocompromised patients due to different conditions, such as chemotherapy, HIV, congenital immunodeficiencies, and transplants.4 It can also be found in many tissues of immunocompetent patients, like the skin.5, 6 We describe 5 adult patients with DRESS syndrome who developed a rash in a lace-like pattern during the disease. Polymerase chain reaction (PCR) studies found parvovirus B19 DNA in skin biopsy specimens obtained from the rash sites in all patients. Therefore, we hypothesize that an association between DRESS syndrome and Parvovirus B19 reactivation may exist. |
| Databáze: | OpenAIRE |
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