Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia
| Autor: | Tiffany W. Chow, Mario Masellis, Alicia A. McNeely, Christopher J.M. Scott, Elizabeth Rochon, Carol Leonard, Sandra E. Black, Naida L. Graham, David F. Tang-Wai |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Diagnostic criteria Cognitive Neuroscience lcsh:Geriatrics Audiology lcsh:RC346-429 050105 experimental psychology Primary progressive aphasia 03 medical and health sciences 0302 clinical medicine Morpheme Apraxia of speech Agrammatism medicine 0501 psychology and cognitive sciences Original Research Article lcsh:Neurology. Diseases of the nervous system 05 social sciences Substitution (logic) medicine.disease lcsh:RC952-954.6 Psychiatry and Mental health Differential diagnosis medicine.symptom Psychology 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Dementia and Geriatric Cognitive Disorders EXTRA Dementia and Geriatric Cognitive Disorders Extra, Vol 6, Iss 3, Pp 407-423 (2016) |
| ISSN: | 1664-5464 |
| Popis: | Background/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. Method: We assessed grammatical production in 9 patients who satisfied current diagnostic criteria. Although the focus was agrammatism, motor speech skills were also evaluated to determine whether dysfluency arose primarily from apraxia of speech (AOS), instead of, or in addition to, agrammatism. Volumetric MRI analyses provided impartial imaging-supported diagnosis. Results: The majority of cases exhibited neither frank agrammatism nor AOS. Conclusion: There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant. |
| Databáze: | OpenAIRE |
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