The global view of mRNA-related ceRNA cross-talks across cardiovascular diseases
| Autor: | Qiuyu Wang, Hong-li Sun, Chao Song, Lina Ba, Wei Huang, Yunping Chen, Jian Zhang, Hanping Qi, Bo Ai, Chunquan Li, Chenchen Feng, Yong-gang Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Multidisciplinary Competing endogenous RNA Mechanism (biology) Gene Expression Profiling lcsh:R Gene regulatory network lcsh:Medicine Computational biology Biology Bioinformatics Common core Article Gene Expression Regulation Neoplastic MicroRNAs 03 medical and health sciences 030104 developmental biology Cardiovascular Diseases Humans Gene Regulatory Networks lcsh:Q RNA Messenger Author Correction lcsh:Science |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Competing endogenous RNA (ceRNA) have received wide attention because they are a novel way to regulate genes through sharing microRNAs (miRNAs) that are crucial for complex processes in many diseases. However, no systematic analysis of ceRNA mechanism in cardiovascular disease (CVD) is known. To gain insights into the global properties of ceRNAs in multi-CVDs, we constructed the global view of mRNA-related ceRNA cross-talk in eight major CVDs from ~2,800 samples. We found common features that could be used to uncover similarities among different CVDs and highlighted a common core ceRNA network across CVDs. Comparative analysis of hub ceRNAs in each network revealed three types of hubs, which might play key roles in diverse biological processes. Importantly, by combining CVD-related pathway genes with ceRNA-ceRNA interactions, common modules that might exert functions in specific mechanisms were identified. In addition, our study investigated a potential mechanistic linkage between pathway cross-talk and ceRNA cross-talk. In summary, this study uncovered and systematically characterized global properties of mRNA-related ceRNA cross-talks across CVDs, which may provide a new layer for exploring biological mechanisms and shed new light on cardiology. |
| Databáze: | OpenAIRE |
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