Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors
| Autor: | Yun Fang Jia, Lee Peyton, Ada Man Choi Ho, Doo Sup Choi, Katheryn Wininger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Obsessive-Compulsive Disorder
medicine.medical_specialty Conditioning Classical Biology medicine.disease_cause Open field Article GLUTAMATE TRANSPORTER 1 Mice 03 medical and health sciences Behavioral Neuroscience Glutamatergic 0302 clinical medicine Jumping Internal medicine medicine Deficient mouse Animals Fear conditioning Obsessive-compulsive disorder (OCD) 030304 developmental biology Mice Knockout 0303 health sciences Behavior Animal Glutamate receptor Fear medicine.disease Grooming Disease Models Animal Endocrinology Excitatory Amino Acid Transporter 2 Astrocytes Locomotion 030217 neurology & neurosurgery |
| Zdroj: | Behav Brain Res |
| Popis: | Glutamatergic dysregulation is known to contribute to obsessive-compulsive disorder (OCD). Astrocytic glutamate transporter 1 (GLT1) is responsible for the majority of glutamate clearance. However, the role of GLT1 in OCD-like behavior remains unclear. Here, we found that astrocytic GLT1 deficient mice showed increased wheel running activity but reduced home cage activity. Notably, they exhibited elevated grooming/rearing time and increased repetitive behavior counts in contextual and cued fear conditioning. In addition, they showed increased rearing counts in the metabolic chamber, and also augmented rearing time and jumping counts in the open field test. Taken together, our findings suggest that astrocytic GLT1 deficiency promotes OCD-like repetitive behaviors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|