Effects of the beta-adrenergic agonist, ritodrine, and insulin on plasma potassium concentrations in fetal lambs
| Autor: | J. C. Mott, C Hanson, J. M. Bassett, C M Weeding, J. Bomford |
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| Rok vydání: | 1992 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Potassium chemistry.chemical_element Pregnancy Internal medicine medicine Animals Insulin Beta (finance) Receptor Fetus Sheep business.industry Osmolar Concentration General Medicine Adrenergic beta-Agonists medicine.disease Fetal Blood Endocrinology Glucose chemistry Ritodrine Female business medicine.drug |
| Zdroj: | Experimental physiology. 77(4) |
| ISSN: | 0958-0670 |
| Popis: | Prolonged infusion of the beta 2-adrenergic agonist, ritodrine, into sheep during late pregnancy decreased maternal plasma K+ from 3.6 to 2.5 mmol l-1 during the first 6-8 h of infusion, as it does during tocolysis in women. This decrease was not accompanied by significant change in fetal plasma K+ concentration. Ritodrine infusion (1-3.5 micrograms kg-1 min-1) directly into the fetus also did not decrease fetal plasma K+ significantly. In contrast, insulin (2.5 mU kg-1 min-1), infused together with glucose (3.6 mg kg-1 min-1) directly into the fetus decreased fetal plasma K+ concentration by 0.8 mmol l-1 within 1 h. The results suggest immaturity in beta 2-adrenergic receptor regulation of electrogenic K+ uptake by muscle in fetal lambs. |
| Databáze: | OpenAIRE |
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