Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-C-13]pyruvate magnetic resonance spectroscopy
| Autor: | Thomas Ravn Lassen, Marie A. Schroeder, Steffen Ringgaard, Hans Stødkilde-Jørgensen, Won Yong Kim, Christoffer Laustsen, Henrik Wiggers, Hans Erik Bøtker, Rasmus Stilling Tougaard, Haiyun Qi, Esben Søvsø Szocska Hansen, Jakob Lindhardt, Nichlas Riise Jespersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
MRS Ejection fraction animal models of human disease business.industry Sham surgery heart failure Metabolism Carbohydrate metabolism medicine.disease Placebo myocardial infarction Internal medicine Heart failure medicine Cardiology Radiology Nuclear Medicine and imaging Myocardial infarction business Ventricular remodeling metabolism remodeling |
| Zdroj: | Tougaard, R S, Laustsen, C, Lassen, T R, Qi, H, Lindhardt, J L, Schroeder, M, Jespersen, N R, Hansen, E S S, Ringgaard, S, Bøtker, H E, Kim, W Y, Stødkilde-Jørgensen, H & Wiggers, H 2022, ' Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-C-13]pyruvate magnetic resonance spectroscopy ', Magnetic Resonance in Medicine, vol. 87, no. 1, pp. 57-69 . https://doi.org/10.1002/mrm.28964 |
| DOI: | 10.1002/mrm.28964 |
| Popis: | Purpose: Hyperpolarized [1- 13C]pyruvate MRS can measure cardiac metabolism in vivo. We investigated whether [1- 13C]pyruvate MRS could predict left ventricular remodeling following myocardial infarction (MI), long-term left ventricular effects of heart failure medication, and could identify responders to treatment. Methods: Thirty-five rats were scanned with hyperpolarized [1- 13C]pyruvate MRS 3 days after MI or sham surgery. The animals were re-examined after 30 days of therapy with β-blockers and ACE-inhibitors (active group, n = 12), placebo treatment (placebo group, n = 13) or no treatment (sham group, n = 10). Furthermore, heart tissue mitochondrial respiratory capacity was assessed by high-resolution respirometry. Metabolic results were compared between groups, over time and correlated to functional MR data at each time point. Results: At 30 ± 0.5 days post MI, left ventricular ejection fraction (LVEF) differed between groups (sham, 77% ± 1%; placebo, 52% ± 3%; active, 63% ± 2%, P 13C]pyruvate MRS and respirometry, neither differed between groups nor between baseline and follow-up. Three days post MI, low bicarbonate + CO 2/pyruvate ratio was associated with low LVEF. At follow-up, in the active group, a poor recovery of LVEF was associated with high bicarbonate + CO 2/pyruvate ratio, as measured by hyperpolarized MRS. Conclusion: In a rat model of moderate heart failure, medical treatment improved function, but did not on average influence [1- 13C]pyruvate flux as measured by MRS; however, responders to heart failure medication had reduced capacity for carbohydrate metabolism. |
| Databáze: | OpenAIRE |
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