Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment
Autor: | Huaye Zhang, Anthony P. Pawlak, Sara L. Sherman, George C. Wagner, Janace J. Gifford, Alexander W. Kusnecov, Anna Derbaly, Sara A. Norton |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Elevated plus maze medicine.medical_specialty Dendritic spine Autism Spectrum Disorder Impulsivity Mice 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Animals Medicine Social Behavior Valproic Acid business.industry Aggression General Neuroscience medicine.disease Disease Models Animal 030104 developmental biology Endocrinology Disinhibition Autism spectrum disorder Conduct disorder Prenatal Exposure Delayed Effects Female lipids (amino acids peptides and proteins) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Neuroscience. 434:8-21 |
ISSN: | 0306-4522 |
Popis: | Valproic acid (VPA) administered to mice during the early postnatal period causes social, cognitive, and motor deficits similar to those observed in humans with autism spectrum disorder (ASD). However, previous studies on the effects of early exposure to VPA have largely focused on behavioral deficits occurring before or during the juvenile period of life. Given that ASD is a life-long condition, the present study ought to extend our understanding of the behavioral profile following early postnatal VPA into adulthood. Male mice treated with VPA on postnatal day 14 (P14) displayed increased aggression, decreased avoidance of the open arms in the elevated plus maze, and impaired reversal learning in the Y maze. This may indicate a disinhibited or impulsive phenotype in male, but not female, mice treated with VPA during the second week of postnatal life. Decreased dendritic spine density and dendritic spine morphological abnormalities in the mPFC of VPA-treated mice may be indicative of PFC hypofunction, consistent with the observed behavioral differences. Since these types of long-lasting deficits are not exclusively found in ASD, early life exposure to VPA may reflect dysfunction of a neurobiological domain common to several developmental disorders, including ASD, ADHD, and conduct disorder. |
Databáze: | OpenAIRE |
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