Monozygotic twins discordant for systemic lupus erythematosus

Autor:	Allyn G. May‐June, John J. Condemi, Jay Grossman, George N. Abraham, Michael W. Yocum, Christine Waterhouse
Rok vydání:	1975
Předmět:	Adult Immunology Antibodies Viral Antigen-Antibody Reactions Immunoglobulin kappa-Chains Immune system Immunoglobulin lambda-Chains Rheumatology Antigen Pregnancy immune system diseases Diseases in Twins Tetanus Toxoid Humans Lupus Erythematosus Systemic Immunology and Allergy Medicine Hypersensitivity Delayed Pharmacology (medical) Castration Lymphocytes skin and connective tissue diseases Antigens Viral Immunoglobulin Fragments Autoantibodies Lupus erythematosus biology business.industry Antibody titer Toxoid Autoantibody Hemagglutination Tests Twins Monozygotic medicine.disease Hemocyanins biology.protein Female gamma-Globulins Antibody business Anti-SSA/Ro autoantibodies
Zdroj:	Arthritis & Rheumatism. 18:193-200
ISSN:	1529-0131 0004-3591
Popis:	A pair of monozygotic twins discordant for systemic lupus erythematosus(SLE) were studied and no differences noted in their immune respose to tetanus toxoid, keyhole lympet hemocyanin, DNCB, delayed sensitivity, or antibody titers to viruses. Both were noted to have biologically false positive serology at an early age, but only one twon developed SLE. The clinically unaffected twin underwent castration at an early age, suggesting that ovarian hormones may play an important role in the development of SLE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61b847916e1268fbf6817ff7abb124b https://doi.org/10.1002/art.1780180301 Zobrazit plný text záznamu Plný text