Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre-school children: a follow-up community-based study
| Autor: | G. J. Arason, B. Árdal, Bjorn R. Ludviksson, Helgi Valdimarsson, O. Thorarensen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Immunoglobulin A
Saliva Allergy Time Factors Immunology Immunoglobulin E Statistics Nonparametric Dermatitis Atopic Immunopathology Hypersensitivity Immunology and Allergy Medicine Humans Asthma Skin Tests biology business.industry Infant Newborn Rhinitis Allergic Seasonal medicine.disease Child Preschool Immunoglobulin G Cohort biology.protein business Cohort study Follow-Up Studies |
| Zdroj: | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 35(1) |
| ISSN: | 0954-7894 |
| Popis: | Summary Background We have previously reported an association between low IgA and allergic manifestations in early childhood (0–2 years) and have now followed our cohort for an additional 2 years. Objective To evaluate in a longitudinal community-based cohort study the association between maturation of Ig production and allergic manifestations in the first 4 years of life. Methods A cohort of 161 randomly selected children was followed from birth to the age of 42–48 months and evaluated at 18–23 months (EV1; n=179) and again at the age of 42–48 months (EV2; n=161). Diagnoses were made with the help of a clinical questionnaire, physical examination and skin prick tests (SPTs) to 10 common allergens. Serum immunoglobulins were measured at EV1 and EV2, and salivary IgA (sal-IgA) at EV2. Results Serum IgA, IgE, IgG1, IgG2 and IgG4 increased from 2 to 4 years of age (P |
| Databáze: | OpenAIRE |
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