Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats
| Autor: | Alain M. Bron, C. Schnebelen, B. Pasquis, Cynthia Fourgeux, Niyazi Acar, Catherine Creuzot-Garcher, Lionel Bretillon |
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| Přispěvatelé: | Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
MESH : RNA Messenger MESH: Eicosapentaenoic Acid Endocrinology Diabetes and Metabolism medicine.medical_treatment [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition Interleukin-1beta MESH: Dietary Supplements MESH: Rats Sprague-Dawley Rats Sprague-Dawley chemistry.chemical_compound 0302 clinical medicine Endocrinology MESH: Interleukin-1beta rat MESH: Animals Prostaglandin E2 Prostaglandin E1 MESH : Tumor Necrosis Factor-alpha MESH : Intraocular Pressure 0303 health sciences Nutrition and Dietetics MESH : Rats MESH : Neuroglia MESH: Retina MESH: Dinoprostone pression intraoculaire MESH: Alprostadil MESH: Docosahexaenoic Acids Biochemistry Eicosapentaenoic Acid Docosahexaenoic acid lipids (amino acids peptides and proteins) MESH: Neuroglia Prostaglandin D2 Cell activation Neuroglia MESH : Alprostadil medicine.drug Prostaglandin E medicine.medical_specialty MESH : Dinoprostone MESH : Interleukin-6 Docosahexaenoic Acids MESH: Rats MESH : Male Prostaglandin Biology MESH : Interleukin-1beta Dinoprostone Retina MESH : Diet 03 medical and health sciences MESH: Diet MESH: Intraocular Pressure Internal medicine medicine MESH : Eicosapentaenoic Acid Animals MESH : Dietary Supplements RNA Messenger Alprostadil prostanoids 030304 developmental biology MESH: RNA Messenger Interleukin-6 Tumor Necrosis Factor-alpha dietary polyunsatured fatty acid retinal stress MESH : Retina Retinal N-6 MESH: Interleukin-6 MESH : Rats Sprague-Dawley eye diseases MESH: Male MESH : Docosahexaenoic Acids Diet Rats N-3 chemistry MESH: Tumor Necrosis Factor-alpha Dietary Supplements 030221 ophthalmology & optometry MESH : Animals sense organs [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition intraocular pressure |
| Zdroj: | Nutrition Research Nutrition Research, Elsevier, 2011, 31 (4), pp.286-95. ⟨10.1016/j.nutres.2011.03.011⟩ Nutrition Research, Elsevier, 2011, 31 (4), pp.286-95. 〈10.1016/j.nutres.2011.03.011〉 |
| ISSN: | 0271-5317 |
| Popis: | International audience; N-6 and n-3 polyunsaturated fatty acids (PUFAs) have been shown to prevent tissue release of inflammatory molecules. We have shown that a combination of n-6 and n-3 PUFAs is more efficient than single supplementations on the long-term consequences of intraocular pressure elevation. We hypothesized that such an association is also more effective during early retinal stress by modifying retinal proinflammatory prostaglandin and cytokine productions. Rats were supplemented for 3 months with n-6 PUFAs, n-3 PUFAs, or both n-6 and n-3 PUFAs. After 3 months, a surgical elevation of intraocular pressure was induced. Retinal morphometry and glial cell activation were evaluated 24 hours after laser treatment. The retinal levels of prostaglandin E(1) (PGE(1)) and prostaglandin E(2) (PGE(2)) and the messenger RNA levels of interleukin-1β, interleukin-6, and tumor necrosis factor-α were measured. Retinal glial cell activation after laser treatment was partly prevented by dietary n-6, n-3, and n-6 and n-3 PUFAs. Retinal PGE(1) was unaffected by the laser treatment or by the diet. Dietary n-6 and/or n-3 PUFAs prevented the increase in PGE(2) levels observed in laser-treated retinas without affecting the induction of interleukin-1β, interleukin-6, and tumor necrosis factor-α messenger RNAs. This study shows that not only a combination of n-6 and n-3 PUFAs but also single supplementations can preserve the retina from early glial cell activation and PGE(2) release. The protective effect is not mediated by changes in cytokine expression but may be related to modifications in retinal prostaglandin metabolism. |
| Databáze: | OpenAIRE |
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