Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study
Autor: | Mengyun Wang, Xiao Nan Hong, Zhi yu Chen, Jiucun Wang, Jing He, Xue Jun Ma, Kai Qin Xia, Qingyi Wei, Yajun Yang, Yan Zhang, Meng Hong Sun, Li Jin, Xiao Yan Zhou |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Male
Candidate gene Epidemiology immune system diseases hemic and lymphatic diseases Medicine Young adult Non-Hodgkin lymphoma Aged 80 and over Molecular Epidemiology Multidisciplinary Lymphoma Non-Hodgkin Cancer Risk Factors Hematology Middle Aged Chinese people Oncology Genetic Epidemiology Female Lymphomas medicine.symptom Cancer Epidemiology Research Article Adult Adolescent Clinical Research Design Science Genetic Causes of Cancer Inflammation Polymorphism Single Nucleotide Young Adult Asian People Genetic variation Humans Genetic Predisposition to Disease neoplasms Biology Aged Population Biology business.industry Case-control study medicine.disease Non-Hodgkin's lymphoma Lymphoma Case-Control Studies Immunology Hematologic cancers and related disorders Genetic Polymorphism business Apoptosis Regulatory Proteins Population Genetics |
Zdroj: | PLoS ONE, Vol 7, Iss 5, p e37846 (2012) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | BackgroundNon-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population.MethodWe used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI).ResultsWe observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR = 3.03; 95% CI = 1.68-5.45 for TT vs. CC and adjusted OR = 2.03; 95% CI = 1.53-2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40-60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin's lymphoma was elevated for CT/TT genotypes (adjusted OR = 1.95, 95% CI = 1.41-2.70 for B cell NHL and adjusted OR = 2.22, 95% CI = 1.49-3.30 for T cell NHL), particularly for DLBCL (adjusted OR = 2.01, 95%CI = 1.41-2.85) and FL (adjusted OR = 2.53, 95% CI = 1.17-5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes.ConclusionsThe polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results. |
Databáze: | OpenAIRE |
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