Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study

Autor: Mengyun Wang, Xiao Nan Hong, Zhi yu Chen, Jiucun Wang, Jing He, Xue Jun Ma, Kai Qin Xia, Qingyi Wei, Yajun Yang, Yan Zhang, Meng Hong Sun, Li Jin, Xiao Yan Zhou
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Candidate gene
Epidemiology
immune system diseases
hemic and lymphatic diseases
Medicine
Young adult
Non-Hodgkin lymphoma
Aged
80 and over
Molecular Epidemiology
Multidisciplinary
Lymphoma
Non-Hodgkin
Cancer Risk Factors
Hematology
Middle Aged
Chinese people
Oncology
Genetic Epidemiology
Female
Lymphomas
medicine.symptom
Cancer Epidemiology
Research Article
Adult
Adolescent
Clinical Research Design
Science
Genetic Causes of Cancer
Inflammation
Polymorphism
Single Nucleotide
Young Adult
Asian People
Genetic variation
Humans
Genetic Predisposition to Disease
neoplasms
Biology
Aged
Population Biology
business.industry
Case-control study
medicine.disease
Non-Hodgkin's lymphoma
Lymphoma
Case-Control Studies
Immunology
Hematologic cancers and related disorders
Genetic Polymorphism
business
Apoptosis Regulatory Proteins
Population Genetics
Zdroj: PLoS ONE, Vol 7, Iss 5, p e37846 (2012)
PLoS ONE
ISSN: 1932-6203
Popis: BackgroundNon-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population.MethodWe used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI).ResultsWe observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR = 3.03; 95% CI = 1.68-5.45 for TT vs. CC and adjusted OR = 2.03; 95% CI = 1.53-2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40-60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin's lymphoma was elevated for CT/TT genotypes (adjusted OR = 1.95, 95% CI = 1.41-2.70 for B cell NHL and adjusted OR = 2.22, 95% CI = 1.49-3.30 for T cell NHL), particularly for DLBCL (adjusted OR = 2.01, 95%CI = 1.41-2.85) and FL (adjusted OR = 2.53, 95% CI = 1.17-5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes.ConclusionsThe polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results.
Databáze: OpenAIRE
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