Possible association between the gamma-aminobutyric acid type B receptor 1 (GABBR1) gene and schizophrenia
| Autor: | Gregory W.H. Wong, Cathy L. Barr, Gwyneth Zai, Nicole King, James L. Kennedy |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Genetic Markers Male Linkage disequilibrium Genotype Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Linkage Disequilibrium Gene Frequency Humans Pharmacology (medical) Family Allele GABBR1 Allele frequency 3' Untranslated Regions Biological Psychiatry Alleles Pharmacology Genetics Psychiatric Status Rating Scales Haplotype Transmission disequilibrium test DNA Exons Genotype frequency Psychiatry and Mental health Neurology Amino Acid Substitution Haplotypes Receptors GABA-B Case-Control Studies Schizophrenia Female Schizophrenic Psychology Neurology (clinical) |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 15(3) |
| ISSN: | 0924-977X |
| Popis: | Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a genetic component. The major inhibitory GABA-(gamma-aminobutyric acid) ergic system may be involved. The GABA type B receptor 1 (GABBR1) gene has been localized to 6p21.3, a region linked to SCZ. We therefore investigated five polymorphisms (A-7265G, C10497G, Ser-491-Ser-T1473C, Phe-659-Phe-T1977C, and 3'-UTR A33795G substitutions) in the GABBR1 gene in a sample of 101 DSM-IV SCZ probands and their families, 150 unrelated affected individuals matched with 150 healthy controls, using the transmission disequilibrium test (TDT) and case-control analysis. We did not observe biased transmission of alleles in any of the polymorphisms individually and haplotypes within the gene to SCZ probands. However, a weak significant difference was observed in the A-7265G polymorphism between the allelic frequency (chi2 = 4.310, P = 0.038) and a trend was observed between the genotype frequency (chi2 = 4.970, 2 df, P = 0.083) of SCZ individuals and controls. Further investigations of the role of GABBR1 in SCZ are warranted. |
| Databáze: | OpenAIRE |
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