Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders

Autor: Ian P. Everall, Vadim Gospodarev, Ben Gouaux, Cristian L. Achim, Virawudh Soontornniyomkij, Eliezer Masliah, Nicole S. Yin, Harry V. Vinters, David J. Moore, Erick T. Tatro
Rok vydání: 2012
Předmět:
Male
AIDS Dementia Complex
HIV dementia
Gene Expression
Hepacivirus
NR3C1
Methamphetamine
Glucocorticoid receptor
2.1 Biological and endogenous factors
Chronic stress
Aetiology
Chronic
Cognitive decline
Middle Aged
Hepatitis C
Immunohistochemistry
FKBP5
Infectious Diseases
Mental Health
medicine.anatomical_structure
FKBP4
Anti-Retroviral Agents
Neurology
Medical Microbiology
HIV/AIDS
Parahippocampal Gyrus
Female
Signal transduction
Infection
Psychology
Parahippocampal gyrus
Signal Transduction
medicine.drug
Adult
Substance-Related Disorders
Physiological
Clinical Sciences
Stress
Article
Tacrolimus Binding Proteins
Cellular and Molecular Neuroscience
Clinical Research
Stress
Physiological
Virology
Behavioral and Social Science
medicine
Humans
Neurosciences
Hepatitis C
Chronic
Brain Disorders
Good Health and Well Being
Immunophilin
Case-Control Studies
Immunology
Neurology (clinical)
Neurocognitive
Zdroj: Journal of neurovirology, vol 18, iss 4
Soontornniyomkij, V; Everall, IP; Moore, DJ; Gouaux, B; Tatro, ET; Gospodarev, V; et al.(2012). Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. Journal of NeuroVirology, 18(4), 313-322. doi: 10.1007/s13365-011-0076-8. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/72w2c81h
ISSN: 1538-2443
1355-0284
DOI: 10.1007/s13365-011-0076-8
Popis: FK506 binding protein (FKBP)-51 and FKBP52 act as molecular chaperones to control glucocorticoid receptor (GR) sensitivity. Dysregulation of proteins involved in GR-mediated signaling can lead to maladaptive stress response and aging-related cognitive decline. As HIV infection is related to chronic stress, we hypothesized that altered cortical expression of these proteins was associated with HIV-associated neurocognitive disorders (HAND). We used quantitative immunohistochemistry to assess expression levels of these proteins in the mid-frontal gyrus of 55 HIV-infected subjects free of cerebral opportunistic diseases compared to 20 age-matched non-HIV controls. The immu-noreactivity normalized to the neuroanatomic area measured (IRn) for FKBP51 was increased in HIV subjects both in the cortex and subcortical white matter (p
Databáze: OpenAIRE
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