Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
| Autor: | Nelesh P. Govender, Rindidzani E. Magobo, Tsidiso G. Maphanga, Serisha D. Naicker, Warren Lowman, Nkosinathi Luthuli, Thokozile G. Zulu |
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| Rok vydání: | 2016 |
| Předmět: |
Echinocandin resistance
0301 basic medicine Echinocandin 030106 microbiology Mutant Case Report Candida glabrata Biology Microbiology South Africa 03 medical and health sciences polycyclic compounds medicine lcsh:QH301-705.5 Gene lcsh:R5-920 biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Infectious Diseases lcsh:Biology (General) lcsh:Medicine (General) Echinocandins medicine.drug |
| Zdroj: | Medical Mycology Case Reports Medical Mycology Case Reports, Vol 11, Iss C, Pp 24-26 (2016) |
| ISSN: | 2211-7539 |
| Popis: | Echinocandins are recommended as first-line agents to treat invasive infections caused by Candida glabrata since this organism is inherently less susceptible to azoles. However, resistance to echinocandins has been described in C. glabrata due to amino acid changes in the hotspot regions of the FKS1 and FKS2 genes. In this report, we describe the first two South African C. glabrata isolates with echinocandin resistance mediated by mutations in the FKS2 gene. Both isolates were cultured from urine specimens from private-sector patients. |
| Databáze: | OpenAIRE |
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