Epstein-Barr Virus-Positive Undifferentiated Thymic Carcinoma in a 12-Year-Old White Girl
| Autor: | Jean Louis Stephan, Eric Delabesse, Simone Boucheron, Elisabeth Macintyre, François Varlet, Claire Galambrun |
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| Rok vydání: | 2000 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human Pathology medicine.medical_specialty Thymoma medicine.disease_cause Virus Herpesviridae hemic and lymphatic diseases medicine Carcinoma Humans Gammaherpesvirinae Child Thymic carcinoma biology business.industry Epstein-Barr Virus Positive Thymus Neoplasms biology.organism_classification medicine.disease Epstein–Barr virus DNA Viral RNA Viral Female business Carcinogenesis |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 22:162-166 |
| ISSN: | 0192-8562 |
| DOI: | 10.1097/00043426-200003000-00016 |
| Popis: | Thymic epithelial malignant diseases are extremely rare in children. The authors report a 12-year-old white girl admitted for a polymetastatic tumor of the anterior mediastinum. Tumor proliferation was typical of an undifferentiated thymic carcinoma. A close link between Epstein-Barr virus (EBV) and the tumor was established by a high titer of anti-VCA IgA and the presence of EBV RNA and DNA in the tumor. In addition, monoclonal viral episomes were present in tumor cells, indicating that EBV infection was an early event in the oncogenic process. The patient died despite resection, irradiation, and chemotherapy. |
| Databáze: | OpenAIRE |
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