Microlocalization and clinical significance of stabilin-1+ macrophages in treatment-naïve patients with urothelial carcinoma of the bladder

Autor: Meihua Yang, Hong Zeng, Wenjuan Yang, Tianxin Lin, Weibin Hou, Zhuowei Liu, Bo Wang, Jian Huang, Hao Huang, Zhihua He
Rok vydání: 2019
Předmět:
Male
Oncology
Nephrology
medicine.medical_specialty
Stromal cell
Stabilin-1
Cell Adhesion Molecules
Neuronal
Urology
medicine.medical_treatment
Lipopolysaccharide Receptors
Receptors
Lymphocyte Homing
030232 urology & nephrology
Antigens
Differentiation
Myelomonocytic
Receptors
Cell Surface
Immunofluorescence
Disease-Free Survival
Cystectomy
03 medical and health sciences
0302 clinical medicine
Antigens
CD
Risk Factors
Internal medicine
Tumor-Associated Macrophages
Tumor Microenvironment
medicine
Humans
Lectins
C-Type
Clinical significance
Aged
Neoplasm Staging
Retrospective Studies
Carcinoma
Transitional Cell
medicine.diagnostic_test
Urothelial carcinoma of the bladder
business.industry
CD68
Middle Aged
Survival Rate
Mannose-Binding Lectins
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Microlocalization
Immunohistochemistry
Original Article
Female
Neoplasm Grading
business
CD163
Mannose Receptor
Zdroj: World Journal of Urology
ISSN: 1433-8726
0724-4983
DOI: 10.1007/s00345-019-02853-0
Popis: Purpose Emerging evidence has shown that macrophages (Mφs) at different tumor sites have diverse clinical attributes. Stabilin-1 is a multi-functional scavenger marker for specialized tumor-associated Mφs. This study investigates the relationship between the density and microlocalization of stabilin-1+ Mφs within tumors and the clinical outcomes of patients with urothelial carcinoma of the bladder (UCB). Methods In this retrospective study, 283 UCB patients who received radical cystectomy or transurethral resection were examined. Immunohistochemistry and immunofluorescence analyses were used to colocalize the expression of stabilin-1 with other markers for Mφs (CD14, CD68, CD163, and CD206). Kaplan–Meier analysis and Cox proportional hazards regression models were applied to estimate overall survival (OS) and recurrence-free survival (RFS). Results In UCB tissues, stabilin-1 was primarily expressed on Mφs, as evident from triple immunofluorescence staining for stabilin-1 and Mφ markers. Stabilin-1+ Mφs were often more prominent in stromal regions rather than intratumoral regions in UCB tissues (P
Databáze: OpenAIRE
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