Sessile serrated adenoma shares similar genetic and epigenetic features with microsatellite unstable colon cancer in a location-dependent manner
| Autor: | Hidenori Kamiyama, Shingo Tsujinaka, Takafumi Maeda, Mitsuhiro Nokubi, Masaaki Saito, Kazutomo Togashi, Fumio Konishi, Koichi Suzuki |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
CpG Island Methylator Phenotype Colorectal cancer Cancer Microsatellite instability Articles General Medicine Biology medicine.disease medicine.disease_cause digestive system diseases Immunology and Microbiology (miscellaneous) Tubular adenoma medicine Cancer research KRAS Carcinogenesis neoplasms Sessile serrated adenoma |
| Zdroj: | Experimental and Therapeutic Medicine. 2:695-700 |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2011.249 |
| Popis: | Genetic and epigenetic features of sessile serrated adenoma (SSA), a precursor lesion to colon cancer with microsatellite instability (MSI), were investigated. The aim of this study was to clarify whether there are location-dependent genetic and epigenetic features in SSA. Twenty-two patients with proximal SSAs and 8 with distal SSAs were recruited. Twenty-two patients with tubular adenoma (TA) and 66 with proximal colon cancer were studied for comparison. Genetic and epigenetic features were evaluated as BRAF and KRAS mutations, MSI, hMLH1 methylation and CpG island methylator phenotype (CIMP). BRAF mutation (p=0.007) and CIMP (p=0.012) were more frequently found in proximal than in distal SSAs. Furthermore, the KRAS mutation was found only in distal SSAs. In TAs, no location-related molecular features were observed. All SSAs, TAs and 42 colon cancer lesions were microsatellite stable (MSS). Twenty-four colon cancer lesions exhibited MSI and had more frequent BRAF mutations (p |
| Databáze: | OpenAIRE |
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