Immediate responses of leukocytes, cytokines and glucocorticoid hormones in the blood circulation of monkeys following challenge with aerosolized staphylococcal enterotoxin B
| Autor: | Jeenan Tseng, A J Johnson, D L Ruble, M L Pitt, Ching-Feng Weng, Jack Komisar, R E Hunt |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Hydrocortisone Lipopolysaccharide Interferon type II T-Lymphocytes medicine.medical_treatment Lymphocyte Immunology Adrenocorticotropic hormone Biology Lymphocyte Activation Enterotoxins chemistry.chemical_compound Adrenocorticotropic Hormone Aldesleukin Internal medicine Concanavalin A medicine Animals Humans Immunology and Allergy Glucocorticoids Aerosols Toxic shock syndrome HLA-DR Antigens General Medicine T lymphocyte medicine.disease Macaca mulatta Killer Cells Natural Endocrinology Cytokine medicine.anatomical_structure chemistry Leukocytes Mononuclear Cytokines Female Mitogens medicine.drug |
| Zdroj: | International Immunology. 9:1825-1836 |
| ISSN: | 1460-2377 |
| DOI: | 10.1093/intimm/9.12.1825 |
| Popis: | The immediate responses to aerosolized staphylococcal enterotoxin B (SEB) in respiratory toxic shock were studied in the circulation of rhesus monkeys with low antibody levels following immunization with SEB toxoid-containing microspheres. Both the surviving and dying monkeys had toxic shock syndrome 4‐48 h after SEB challenge and all showed three distinctive patterns of immediate responses. The first pattern, characterized by the responses of all T cells, HLA-DR lo cells, monocytes, IL-2R F cells, IFN-g, and augmented lymphocyte mitotic responses to lipopolysaccharide (LPS) and SEB in culture, was a rapid increase at 20 min followed by a quick decrease at 90 min to approximately the original levels. The second pattern, which included responses of HLA-DR hi cells, NK cells, adrenocorticotropic hormone (ACTH) and cortisol, was characterized by a moderate decrease at 20 min and a further decrease at 90 min. The third pattern, the inverse of the second pattern, including responses of polymorphonuclear leukocytes (PMN), concanavalin A (Con A) mitogenesis, IL-6 and IL-2, was a moderate increase at 20 min and a further increase at 90 min. Between the surviving and dying monkeys, the responses of T cells, HLA-DR hi cells, PMN and cortisol did not differ significantly, suggesting that they are the basic causes that initiated toxic shock. However, significant differences were seen in the responses of HLA-DR lo cells, monocytes, IL-2R F cells and lymphocyte mitogenesis in culture at 20 min, and of Con A mitogenesis, NK cells, IL-2, IL-6 and ACTH at 90 min. These different responses are apparently the exacerbating causes of death of the monkeys. All together, the immediate responses seem to be caused by the combined effects of SEB superantigenicity, activation of NK cells and non-lymphoid cells, and depression of the neuroimmune defense system. |
| Databáze: | OpenAIRE |
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