HLA patterns in patients with nasal polyposis
| Autor: | Andrea Berghold, D. Lang-Loidolt, W. Luxenberger, T. Hofmann, U. Posch |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Allergy Nose Neoplasms Gastroenterology Cystic fibrosis Pathogenesis Drug Hypersensitivity Nasal Polyps HLA Antigens Risk Factors Internal medicine otorhinolaryngologic diseases medicine Humans Nasal polyps Nose Asthma Primary ciliary dyskinesia Aspirin HLA-A Antigens business.industry General Medicine respiratory system medicine.disease medicine.anatomical_structure Phenotype Otorhinolaryngology Immunology Etiology business |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 257(3) |
| ISSN: | 0937-4477 |
| Popis: | The etiology of nasal polyposis is still unknown, although risk factors include Aspirin intolerance, asthma, cystic fibrosis and primary ciliary dyskinesia. We studied frequencies of HLA A, B, DR and DQ in patients with nasal polyposis in order to determine a possible genetic component in the multifactorial pathogenesis of nasal polyps. Previous work has suggested an association of HLA-A1B8 with nasal polyposis and Aspirin intolerance. We investigated 89 patients with nasal polyposis, 11 of whom had Aspirin-intolerance, 19 asthma and 22 allergies to inhalation allergens. HLA patterns of these patients were compared to the ones of 1,070 healthy controls. No significant association of HLA-A1B8 was found with nasal polyps in the Aspirin-sensitive subgroup of our patients, but a significant association was seen with HLA-A74 and nasal polyposis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink